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聚甲基丙烯酸甲酯与抗菌季铵盐表面活性剂的杂化纳米颗粒

Hybrid Nanoparticles of Poly (Methyl Methacrylate) and Antimicrobial Quaternary Ammonium Surfactants.

作者信息

Mathiazzi Beatriz Ideriha, Carmona-Ribeiro Ana Maria

机构信息

Biocolloids Laboratory, Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes 748, 05508-000 São Paulo, Brazil.

出版信息

Pharmaceutics. 2020 Apr 10;12(4):340. doi: 10.3390/pharmaceutics12040340.

DOI:10.3390/pharmaceutics12040340
PMID:32290276
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7238100/
Abstract

Quaternary ammonium surfactants (QACs) are microbicides, whereas poly (acrylates) are biocompatible polymers. Here, the physical and antimicrobial properties of two QACs, cetyl trimethyl ammonium bromide (CTAB) or dioctadecyl dimethyl ammonium bromide (DODAB) in poly (methyl methacrylate) (PMMA) nanoparticles (NPs) are compared to those of QACs alone. Methyl methacrylate (MMA) polymerization using DODAB or CTAB as emulsifiers and initiator azobisisobutyronitrile (AIBN) yielded cationic, nanometric, homodisperse, and stable NPs. NPs' physical and antimicrobial properties were assessed from dynamic light scattering (DLS), scanning electron microscopy, and viability curves of , , or determined as log(colony-forming unities counting) over a range of [QACs]. NPs were spherical and homodisperse but activity for free QACs was higher than those for QACs in NPs. Inhibition halos against bacteria and yeast were observed only for free or incorporated CTAB in NPs because PMMA/CTAB NPs controlled the CTAB release. DODAB displayed fungicidal activity against since DODAB bilayer disks could penetrate the outer glycoproteins fungus layer. The physical properties and stability of the cationic NPs highlighted their potential to combine with other bioactive molecules for further applications in drug and vaccine delivery.

摘要

季铵表面活性剂（QACs）是杀菌剂，而聚（丙烯酸酯）是生物相容性聚合物。在此，将聚（甲基丙烯酸甲酯）（PMMA）纳米颗粒（NPs）中两种QACs，即十六烷基三甲基溴化铵（CTAB）或二辛基二甲基溴化铵（DODAB）的物理和抗菌性能与单独的QACs进行比较。以DODAB或CTAB为乳化剂、偶氮二异丁腈（AIBN）为引发剂进行甲基丙烯酸甲酯（MMA）聚合，得到阳离子、纳米级、均分散且稳定的NPs。通过动态光散射（DLS）、扫描电子显微镜以及在一系列[QACs]范围内测定的金黄色葡萄球菌、大肠杆菌或白色念珠菌的活力曲线来评估NPs的物理和抗菌性能。NPs呈球形且均分散，但游离QACs的活性高于NPs中QACs的活性。仅游离的或包封在NPs中的CTAB对细菌和酵母有抑菌圈，因为PMMA/CTAB NPs能控制CTAB的释放。DODAB对白色念珠菌具有杀菌活性，因为DODAB双层盘可穿透真菌外层糖蛋白层。阳离子NPs的物理性质和稳定性突出了它们与其他生物活性分子结合以进一步应用于药物和疫苗递送的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb5/7238100/4bcefbd8da5f/pharmaceutics-12-00340-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb5/7238100/881d845253c6/pharmaceutics-12-00340-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb5/7238100/18c08cbf8afe/pharmaceutics-12-00340-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb5/7238100/be1f3bdb7482/pharmaceutics-12-00340-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb5/7238100/06b73d73bd88/pharmaceutics-12-00340-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb5/7238100/23b02d3fb2de/pharmaceutics-12-00340-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb5/7238100/3cc28ae4321c/pharmaceutics-12-00340-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb5/7238100/e1a750cd7c9f/pharmaceutics-12-00340-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb5/7238100/dec9a12b4bc6/pharmaceutics-12-00340-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb5/7238100/4bcefbd8da5f/pharmaceutics-12-00340-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb5/7238100/881d845253c6/pharmaceutics-12-00340-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb5/7238100/18c08cbf8afe/pharmaceutics-12-00340-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb5/7238100/be1f3bdb7482/pharmaceutics-12-00340-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb5/7238100/06b73d73bd88/pharmaceutics-12-00340-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb5/7238100/23b02d3fb2de/pharmaceutics-12-00340-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb5/7238100/3cc28ae4321c/pharmaceutics-12-00340-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb5/7238100/e1a750cd7c9f/pharmaceutics-12-00340-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb5/7238100/dec9a12b4bc6/pharmaceutics-12-00340-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eb5/7238100/4bcefbd8da5f/pharmaceutics-12-00340-g008.jpg

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