School of Biosciences and Veterinary Medicine, University of Camerino, Via Gentile III da Varano, 62032 Camerino, Italy.
Nutrients. 2020 Apr 10;12(4):1051. doi: 10.3390/nu12041051.
Beside skeletal system maintenance and protection, possible extra-calcium roles of vitamin D have been recently described. In particular, studies have investigated possible roles of vitamin D as a key modulator of inflammation and immune mechanisms and of the intestinal mucosa barrier. In this regard, vitamin D has been considered as a factor that affects different conditions such as immune-mediated diseases. The new emerging role of vitamin D and its involvement in immune modulation has led it to be considered as a possible key factor involved in celiac disease (CD) onset. CD is a chronic immune-mediated enteropathy of the small intestine that is triggered by dietary gluten protein exposure in individuals who are genetically predisposed. However, along with gluten, other environmental factors are also involved in CD onset. The renewed interest in a molecule that offers great possibilities for new roles has led to an increase in studies, although there remains a lack of studies aimed at contextualizing the role of vitamin D on CD. This review aims to define the possible role of vitamin D in CD onset as it is presently understood, taking into account potential links among vitamin D, the immune system and CD.
除了维护和保护骨骼系统外，维生素 D 可能具有的额外钙作用最近也有描述。特别是，研究已经调查了维生素 D 作为炎症和免疫机制以及肠道黏膜屏障的关键调节剂的可能作用。在这方面，维生素 D 被认为是影响多种疾病的因素，如免疫介导的疾病。维生素 D 的新出现的作用及其在免疫调节中的作用使它被认为是乳糜泻 (CD) 发病的一个可能的关键因素。CD 是一种慢性免疫介导的小肠疾病，是由遗传易感性个体对膳食 gluten 蛋白暴露引发的。然而，除了 gluten 之外，其他环境因素也参与了 CD 的发病。对一种具有新作用的巨大可能性的分子的重新关注导致了更多的研究，尽管仍缺乏旨在使维生素 D 在 CD 中的作用背景化的研究。本综述旨在定义目前已知的维生素 D 在 CD 发病中的可能作用，同时考虑维生素 D、免疫系统和 CD 之间的潜在联系。
