Department of Medical, Oral and Biotechnological Sciences, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy.
Department of Economic Studies, University G. d'Annunzio Chieti-Pescara, 65100 Pescara, Italy.
Int J Mol Sci. 2020 Apr 11;21(8):2669. doi: 10.3390/ijms21082669.
Periodontal disease (PD) is an inflammatory condition of the tissues supporting the teeth, which is widespread among the adult population. Evidence shows a relationship between PD and vitamin D levels, which is involved in the regulation of bone metabolism, mineral homeostasis, and inflammatory response. This study aimed to perform a simultaneous evaluation of inflammatory mediators and vitamin D levels in saliva in periodontopathic patients to better understand their role in periodontal disease. In this observational study, clinical periodontal parameter examination was performed for each patient. Moreover, the saliva levels of 25(OH)D, TGFβ, IL-35, IL-17A, and MMP9 were evaluated using an ELISA assay. An increase in TGFβ, IL-35, MMP9, and IL-17A salivary levels and a reduction in 25(OH)D levels were observed in periodontopathic patients with respect to the healthy controls. The present study revealed significant positive correlation between cytokines and highly negative correlation between 25(OH)D and salivary cytokine levels. Further studies are needed to better understand if salivary cytokines and vitamin D evaluation may represent a new approach for detection and prevention of progressive diseases, such as PD.
牙周病（PD）是一种支持牙齿的组织的炎症性疾病，在成年人群中广泛存在。有证据表明 PD 与维生素 D 水平之间存在关系，维生素 D 参与骨代谢、矿物质稳态和炎症反应的调节。本研究旨在同时评估牙周病患者唾液中的炎症介质和维生素 D 水平，以更好地了解它们在牙周病中的作用。在这项观察性研究中，对每位患者进行了临床牙周参数检查。此外，还使用 ELISA 测定法评估了唾液中的 25(OH)D、TGFβ、IL-35、IL-17A 和 MMP9 水平。与健康对照组相比，牙周病患者的 TGFβ、IL-35、MMP9 和 IL-17A 唾液水平升高，25(OH)D 水平降低。本研究表明细胞因子之间存在显著正相关，25(OH)D 与唾液细胞因子水平之间存在高度负相关。需要进一步的研究来更好地了解唾液细胞因子和维生素 D 的评估是否可以代表一种新的方法来检测和预防 PD 等进行性疾病。
