Bahramian Ayla, Falsafi Parisa, Abbasi Teymour, Ghanizadeh Milad, Abedini Mehdi, Kavoosi Fatemeh, Kouhsoltani Maryam, Noorbakhsh Fatemeh, Dabbaghi Tabriz Fatemeh, Rajaeih Shahin, Rezaei Farzad
Dept. of Oral Medicine, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
Dentist, Tabriz, Iran.
J Dent (Shiraz). 2018 Dec;19(4):295-300.
Recurrent aphthous stomatitis (RAS) is the most prevalent ulcerative condition of the oral mucosa. Many studies have emphasized on immunologic factors as the reason of inducing RAS; however, the exact etiologic cause of RAS has not been identified yet. Vitamin D has an endocrine function and regulatory effects on the immune system. It has potential therapeutic effects on autoimmune diseases, psoriasis, and neoplasms. Vitamin D deficiency has been detected in some autoimmune diseases such as rheumatoid arteritis.
The aim of the present study was to compare the serum and salivary levels of vitamin D in patients with RAS and healthy individuals.
In this cross sectional study, patients with RAS, referring to the Department of Oral Medicine, Tabriz Faculty of Dentistry, were evaluated after taking medical history, clinical examinations, and completing an informed consent form. The serum and salivary vitamin D levels were compared between case (n=26) and control (n=26) groups.
The mean serum vitamin D levels in the case and control groups were 33.0.7±12.41 and 50.89±9.30 (ng/dL), respectively, with a statistically significant difference (<0.001). On the other hand, the mean salivary vitamin D levels in the case and control groups were 17.36± 8.01 and 20.79±6.31 (ng/dL), respectively, with no statistically significant difference (= 0.09). In addition, the correlation between the serum and salivary levels of vitamin D was 56%, being statistically significant (< 0.001).
The serum levels of vitamin D in patients with RAS were significantly less than that in healthy individuals; however, there were no significant differences in salivary vitamin D levels between patients with RAS and healthy individuals. In addition, there was a significant and positive correlation between serum and salivary levels of vitamin D in all patients.
复发性阿弗他口炎（RAS）是口腔黏膜最常见的溃疡性疾病。许多研究强调免疫因素是诱发RAS的原因；然而，RAS的确切病因尚未确定。维生素D具有内分泌功能并对免疫系统有调节作用。它对自身免疫性疾病、银屑病和肿瘤具有潜在治疗作用。在一些自身免疫性疾病如类风湿性动脉炎中已检测到维生素D缺乏。
本研究的目的是比较RAS患者和健康个体血清及唾液中维生素D的水平。
在这项横断面研究中，前往大不里士牙科系口腔医学科就诊的RAS患者在接受病史采集、临床检查并签署知情同意书后进行评估。比较病例组（n = 26）和对照组（n = 26）血清及唾液中维生素D的水平。
病例组和对照组的血清维生素D平均水平分别为33.07±12.41和50.89±9.30（ng/dL），差异有统计学意义（<0.001）。另一方面，病例组和对照组的唾液维生素D平均水平分别为17.36±8.01和20.79±6.31（ng/dL），差异无统计学意义（= 0.09）。此外，血清和唾液中维生素D水平的相关性为56%，差异有统计学意义（< 0.001）。
RAS患者的血清维生素D水平显著低于健康个体；然而，RAS患者与健康个体的唾液维生素D水平无显著差异。此外，所有患者血清和唾液中维生素D水平之间存在显著正相关。
