State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Animal Science and Technology, Guangxi University, Nanning, Guangxi 530004, People's Republic of China.
J Agric Food Chem. 2020 May 6;68(18):5189-5200. doi: 10.1021/acs.jafc.0c01103. Epub 2020 Apr 24.
Zinc deficiency is a risk factor for the development of obesity and diabetes. Studies have shown lower serum zinc levels in obese individuals and those with diabetes. We speculate that zinc supplementation can alleviate obesity and diabetes and, to some extent, their complications. To test our hypothesis, we investigated the effects of zinc supplementation on mice with high-fat diet (HFD)-induced hepatic steatosis and by adding zinc to the diet of mice and the medium of HepG2 cells. Both results showed that high levels of zinc could alleviate the glucose and lipid metabolic disorders induced by a HFD. High zinc can reduce glucose production, promote glucose absorption, reduce lipid deposition, improve HFD-induced liver injury, and regulate energy metabolism. This study provides novel insight into the treatment of non-alcoholic fatty liver disease and glucose metabolic disorder.
锌缺乏是肥胖和糖尿病发展的一个风险因素。研究表明，肥胖者和糖尿病患者的血清锌水平较低。我们推测，补锌可以缓解肥胖和糖尿病及其在一定程度上的并发症。为了验证我们的假设，我们通过在高脂肪饮食（HFD）诱导的肝脂肪变性小鼠的饮食中添加锌以及 HepG2 细胞的培养基中添加锌，研究了补锌对小鼠的影响。这两个结果都表明，高锌水平可以缓解 HFD 引起的葡萄糖和脂质代谢紊乱。高锌可以减少葡萄糖生成，促进葡萄糖吸收，减少脂肪沉积，改善 HFD 引起的肝损伤，并调节能量代谢。本研究为治疗非酒精性脂肪肝和葡萄糖代谢紊乱提供了新的思路。
