墨西哥儿童的膳食锌摄入量以及胰岛素水平和胰岛素抵抗稳态模型评估与端粒缩短的关联

Dietary Zinc Intake and the Association of Insulin Level and HOMA-IR with Telomere Shortening in Mexican Children.

作者信息

Vazquez-Moreno Miguel, Perales-Herrera Araceli, Ramírez-Silva Ivonne, Martínez-Gómez Laura E, García-Cerón Angélica, Paredes-Barrientos Jorge C, Hernández-Mendoza Héctor, Martinez-Garza Sandra, Murillo-Ortiz Blanca, Cruz Miguel

机构信息

Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Av. Cuauhtémoc 330, Col. Doctores, Delegación Cuauhtémoc, C.P. 06720, Ciudad de Mexico, México.

Programa de Licenciatura en Nutrición, Universidad del Centro de México, S.L.P, CP, 78250, San Luis, México.

出版信息

Biol Trace Elem Res. 2025 Apr;203(4):2114-2121. doi: 10.1007/s12011-024-04329-8. Epub 2024 Aug 7.

DOI:10.1007/s12011-024-04329-8

PMID:39110381

Abstract

PURPOSE

The relationship between dietary zinc (Zn) intake, metabolic diseases, and telomere length has been little explored in the children population. This observational cross-sectional study assesses the association between obesity (OB), cardiometabolic traits, telomere length, and dietary Zn intake in children with normal weight (NW) and OB from Mexico City.

METHODS

Anthropometric data, blood pressure, biochemical measurements, the homeostatic model assessment of insulin resistance (HOMA-IR) and leucocyte telomere length (determined by quantitative-PCR) were analyzed in 171 children with NW and 172 with OB. Furthermore, dietary Zn intake was evaluated in 117 children NW and 120 with OB.

RESULTS

Telomere shortening was associated with fasting plasma insulin (FPI) and HOMA-IR in NW (beta coefficient [β] = -0.022 ± 0.008, p = 0.009; β = -0.096 ± 0.040, p = 0.020) and OB (β = -0.007 ± 0.002, p = 0.003; β = -0.034 ± 0.012, p = 0.005) children. Dietary Zn intake resulted negatively associated with FPI (β = -2.418 ± 0.764, p = 0.002) and HOMA-IR (β = -0.399 ± 0.014, p = 0.009) in children with OB. Then, in children with OB, the association between FPI, HOMA-IR, and telomere shortening was evaluated separately in groups of low, medium, and high dietary Zn intake (according to tertiles). The association between FPI, HOMA-IR, and telomere shortening was not significant in the high Zn intake group (P = 0.633; P = 0.567).

CONCLUSION

Our results suggest that a high Zn intake may ameliorate the telomere shortening related to high FPI and HOMA-IR.

摘要

目的

儿童群体中饮食锌（Zn）摄入量、代谢性疾病和端粒长度之间的关系鲜有研究。这项观察性横断面研究评估了墨西哥城正常体重（NW）和肥胖（OB）儿童中肥胖（OB）、心脏代谢特征、端粒长度与饮食锌摄入量之间的关联。

方法

对171名NW儿童和172名OB儿童进行了人体测量数据、血压、生化指标、胰岛素抵抗稳态模型评估（HOMA-IR）以及白细胞端粒长度（通过定量PCR测定）的分析。此外，对117名NW儿童和120名OB儿童的饮食锌摄入量进行了评估。

结果

NW儿童（β系数[β]=-0.022±0.008，p=0.009；β=-0.096±0.040，p=0.020）和OB儿童（β=-0.007±0.002，p=0.003；β=-0.034±0.012，p=0.005）中端粒缩短与空腹血浆胰岛素（FPI）和HOMA-IR相关。在OB儿童中，饮食锌摄入量与FPI（β=-2.418±0.764，p=0.002）和HOMA-IR（β=-0.399±0.014，p=0.009）呈负相关。然后，在OB儿童中，根据饮食锌摄入量的三分位数将其分为低、中、高摄入组，分别评估FPI、HOMA-IR与端粒缩短之间的关联。在高锌摄入组中，FPI、HOMA-IR与端粒缩短之间的关联不显著（P=0.633；P=0.567）。