Hu Dong, Cheng Shasha, Wei Xiaoyan, Man Chaoxin
Key Laboratory of Dairy Science, Ministry of Education, College of Food Science, Northeast Agricultural University, Harbin 150030, China.
Institute of Agro-Resources and Environment/Hebei Fertilizer Technology Innovation Center, Hebei Academy of Agriculture and Forestry Sciences, Shijiazhuang 050000, China.
Nutrients. 2025 Apr 9;17(8):1310. doi: 10.3390/nu17081310.
Disorders of glucose and lipid metabolism can easily lead to metabolic diseases such as hyperlipidemia and diabetes mellitus, with multiple complications. This study evaluated the regulatory effect of purple-grain wheat on glycolipid metabolism. In this study, we established a hyperlipidemic mouse model by means of a high-fat diet and a type 2 diabetic mouse model using a high-fat and high-sugar diet combined with streptozotocin, and the mice were intervened with 15 g/(kg·d), 7.5 g/(kg·d), and 3.75 g/(kg·d) doses of purple-grain wheat paste (PWP) for 4 and 5 weeks, respectively. The results revealed that PWP reversed the increase in body weight; increased serum high-density lipoprotein cholesterol; and decreased serum total cholesterol, triglycerides, and low-density lipoproteins. In addition, PWP reversed the decrease in body weight and alleviated the sustained increase in blood glucose in type 2 diabetic mice. PWP shows a significant ability to regulate glycolipid levels, which is related to its functional composition and its ability to act as a prebiotic. In conclusion, PWP can be considered a potential functional food for lowering blood glucose and blood lipids.
葡萄糖和脂质代谢紊乱容易导致高脂血症和糖尿病等代谢性疾病，并伴有多种并发症。本研究评估了紫粒小麦对糖脂代谢的调节作用。在本研究中，我们通过高脂饮食建立了高脂血症小鼠模型，并使用高脂高糖饮食联合链脲佐菌素建立了2型糖尿病小鼠模型，分别用15 g/(kg·d)、7.5 g/(kg·d)和3.75 g/(kg·d)剂量的紫粒小麦糊（PWP）对小鼠进行4周和5周的干预。结果显示，PWP可逆转体重增加；提高血清高密度脂蛋白胆固醇水平；降低血清总胆固醇、甘油三酯和低密度脂蛋白水平。此外，PWP可逆转2型糖尿病小鼠体重下降的情况，并缓解血糖的持续升高。PWP具有显著的调节糖脂水平的能力，这与其功能成分及其作为益生元的能力有关。总之，PWP可被视为一种潜在的降血糖和降血脂功能性食品。
