Department of Molecular Systems Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Department of Nursing, School of Nursing and Midwifery, Shahroud University of Medical Sciences, Shahroud, Iran.
Hypertens Pregnancy. 2020 May;39(2):196-202. doi: 10.1080/10641955.2020.1753068. Epub 2020 Apr 15.
: The aim of this meta-analysis was to examine the association of ApoE polymorphism with the risk of developing PE.: A comprehensive search was carried out through PubMed, Scopus, and Embase. The ORs with corresponding 95% CIs were extracted. Fixed model was used for meta-analysis and in case of existing heterogeneity a random-effects model was applied.: Association of ApoE polymorphism with the risk of developing PE was not statistically significant (OR = 0.86, 95% CI: 0.67-1.11; OR = 0.92, 95%CI: 0.73-1.15, respectively for ε2 and ε4).: ApoE polymorphism might not be associated with the risk of PE.
本荟萃分析旨在研究载脂蛋白 E 多态性与 PE 发病风险的关联。通过 PubMed、Scopus 和 Embase 进行全面检索。提取相应的 OR 值及其 95%CI。荟萃分析采用固定效应模型，若存在异质性，则采用随机效应模型。载脂蛋白 E 多态性与 PE 发病风险之间无统计学意义相关（OR=0.86，95%CI：0.67-1.11；OR=0.92，95%CI：0.73-1.15，分别为 ε2 和 ε4）。载脂蛋白 E 多态性与 PE 发病风险可能无关。
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