Feng Fang, Lu Shan-Shan, Hu Cai-Yun, Gong Feng-Feng, Qian Zhen-Zhong, Yang Hui-Yun, Wu Yi-Le, Zhao Yuan-Yuan, Bi Peng, Sun Ye-Huan
Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.
Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.
J Clin Neurosci. 2015 Aug;22(8):1232-8. doi: 10.1016/j.jocn.2015.02.012. Epub 2015 May 12.
We performed an updated meta-analysis to obtain a more precise estimation of the relationship between apolipoprotein E (ApoE) gene polymorphism and susceptibility to depression, as previous reports have been inconsistent. Twenty studies with 2286 depression patients and 3845 controls were included. Odds ratios (OR) with 95% confidence intervals (CI) were calculated to assess the association between ApoE gene polymorphism and depression using a random effects model. Results showed a significant association between ApoE gene polymorphism and susceptibility to depression in the overall population (ε2/ε3 genotype versus ε3/ε3: OR 0.76, 95% CI 0.59-0.99). Subgroup analyses indicated an association in the Caucasian population (ε2 allele versus ε3: OR 0.75, 95% CI 0.58-0.97) as well as in late-life depression (LLD) patients (ε3/ε4 genotype versus ε3/ε3: OR 1.34, 95% CI 1.07-1.68, and ε4 allele versus ε3: OR 1.30, 95% CI 1.06-1.59). We concluded that the ε2/ε3 genotype likely provided a protective effect against depression in the overall population and the ε2 allele acted as a protective factor for depression in the Caucasian population while the ε4 allele and ε3/ε4 genotype were associated with an increased risk of depression in the LLD subjects.
由于之前的报告结果不一致，我们进行了一项更新的荟萃分析，以更精确地估计载脂蛋白E（ApoE）基因多态性与抑郁症易感性之间的关系。纳入了20项研究，共2286例抑郁症患者和3845例对照。采用随机效应模型计算比值比（OR）及95%置信区间（CI），以评估ApoE基因多态性与抑郁症之间的关联。结果显示，在总体人群中，ApoE基因多态性与抑郁症易感性之间存在显著关联（ε2/ε3基因型与ε3/ε3基因型相比：OR 0.76，95%CI 0.59-0.99）。亚组分析表明，在白种人群中存在关联（ε2等位基因与ε3等位基因相比：OR 0.75，95%CI 0.58-0.97），在老年抑郁症（LLD）患者中也存在关联（ε3/ε4基因型与ε3/ε3基因型相比：OR 1.34，95%CI 1.07-1.68；ε4等位基因与ε3等位基因相比：OR 1.30，95%CI 1.06-1.59）。我们得出结论，ε2/ε3基因型可能对总体人群的抑郁症具有保护作用，ε2等位基因是白种人群抑郁症的保护因素，而ε4等位基因和ε3/ε4基因型与LLD患者抑郁症风险增加有关。
