Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore, 54690, Pakistan.
Lipids Health Dis. 2020 Apr 14;19(1):73. doi: 10.1186/s12944-020-01248-0.
Obesity has become global epidemic in the last three decades, whereas Coronary Heart Disease (CHD) still remains the most important cause of mortality in the world. The study was aimed at determining the pattern of lipid profile for the obese and CHD population in Pakistan. As obesity is a strong predisposing risk factor for CHD, we aimed to analyze the lipid parameters in both conditions and compare them with the healthy controls of the same ethnicity.
Blood samples were collected from one thousand individuals (500 with CHD, 250 with obesity, 250 healthy controls). The lipid profile (total Cholesterol, triglycerides, HDL-C, LDL-C and VLDL) was measured using commercially available kits. The pattern of dyslipidemia was then studied by comparing the results in both groups with controls as well as population cutoffs. The quantitative variables were checked for normality and log transformation was done for variables where appropriate. Analysis of variance and logistic regression were done to check the association of lipid parameters with obesity and CHD.
The obese and CHD groups showed a dyslipidemic profile than the healthy controls. CHD group had a higher proportion of CHD in any of the first degree blood relatives (36.0% vs. 1.8%), a similar trend was observed in the obese group, where 63.9% cases had positive family history. Among cases, 50.7% had combined lipid abnormalities, i.e., the values of TC, LDL-C, TG and HDL-C, all were deranged. Whereas 49.52% had TC more than normal cut off (> 200 mg/dl), 51.6% had LDL-C > 100 mg/dl. Similarly, 80.4% of patients had TG levels more than upper normal range (> 150 mg/dl) and 64% had HDL values in moderate CHD risk group (< 50 mg/dl). The results show that Pakistani cases are hyperlipidemic for lipid traits except for HDL which is lowered. Patients with comorbidities also had lipid profiles deviated from the normal range.
The study provides information regarding the aberration of lipid profile in the metabolic disorders that can increase the predisposition to complications.
在过去的三十年中，肥胖已成为全球性的流行疾病，而冠心病（CHD）仍然是世界上最重要的死亡原因。本研究旨在确定巴基斯坦肥胖和 CHD 人群的血脂谱模式。由于肥胖是 CHD 的重要致病危险因素，我们旨在分析两种情况下的血脂参数，并将其与同一种族的健康对照组进行比较。
从一千个人中采集血液样本（500 名患有 CHD，250 名患有肥胖症，250 名健康对照组）。使用市售试剂盒测量血脂谱（总胆固醇、甘油三酯、HDL-C、LDL-C 和 VLDL）。然后通过将结果与对照组以及人群切点进行比较，研究血脂异常的模式。对定量变量进行正态性检查，对于合适的变量进行对数转换。进行方差分析和逻辑回归以检查血脂参数与肥胖和 CHD 的相关性。
肥胖和 CHD 组的血脂谱异常高于健康对照组。CHD 组在任何一级血亲中都有更高比例的 CHD（36.0% vs. 1.8%），肥胖组也观察到类似的趋势，其中 63.9%的病例有阳性家族史。在病例中，50.7%有联合血脂异常，即 TC、LDL-C、TG 和 HDL-C 的值均异常。而 49.52%的 TC 值超过正常切点（>200mg/dl），51.6%的 LDL-C 值>100mg/dl。同样，80.4%的患者 TG 水平超过上限（>150mg/dl），64%的患者 HDL 值处于中度 CHD 风险组（<50mg/dl）。结果表明，巴基斯坦患者的血脂特征除了 HDL 降低外，其余均呈高脂血症。患有合并症的患者的血脂谱也偏离了正常范围。
本研究提供了关于代谢紊乱中血脂谱异常的信息，这可能会增加并发症的易感性。
