Division of Adolescent Medicine, Department of Pediatrics, Hospital for Sick Children, Toronto, Canada; University of Toronto, Toronto, Canada.
University of Toronto, Toronto, Canada.
J Adolesc Health. 2020 Oct;67(4):618-620. doi: 10.1016/j.jadohealth.2020.02.022. Epub 2020 Apr 11.
Vitamin C deficiency results in the clinical presentation of scurvy, a disease that is rare among the adolescent population. Individuals with unusual dietary habits, mental illness, or physical disability are more prone to develop scurvy. We present a case report of a previously healthy 16-year-old female presented to the hospital with a 12-month history of anorexia nervosa, restrictive subtype. She was admitted to the intensive care unit and transferred to a tertiary care pediatric eating disorder program for the treatment of extreme weight loss, cardiovascular instability, and refeeding syndrome. On examination, she had multiple tiny hyperpigmented perifollicular petechial papules on the lower abdomen, dorsum thighs, and extensor surfaces of the arms with corkscrew hairs on the abdomen. Dermatologic examination and laboratory investigations were consistent with a diagnosis of scurvy. The patient's vitamin C serum level was 21 μmol/L (.23 mg/dL; reference range 25-114 μmol/L [.28-1.28 mg/dL]). She was treated with ascorbic acid orally. Objective cutaneous findings improved within 4 weeks of supplementation, and after 6 weeks, repeat levels of vitamin C levels were 102 μmol/L (1.15 mg/dL). To the best of our knowledge, this is the first case of an adolescent female with anorexia nervosa and cutaneous manifestations of scurvy that resolved after the oral administration of vitamin C.
维生素 C 缺乏会导致坏血病的临床症状,这种疾病在青少年人群中很少见。有特殊饮食习惯、精神疾病或身体残疾的个体更容易患上坏血病。我们报告了一例先前健康的 16 岁女性,因神经性厌食症(限制型亚型)就诊,病史 12 个月。她被收入重症监护病房,并转至三级儿科饮食失调症治疗中心,以治疗极度体重减轻、心血管不稳定和重新喂养综合征。体格检查时,她的下腹部、大腿背部和手臂伸展面有多个微小的色素性滤泡性瘀点性丘疹,腹部有螺旋状毛发。皮肤科检查和实验室检查结果符合坏血病的诊断。患者的维生素 C 血清水平为 21μmol/L(0.23mg/dL;参考范围 25-114μmol/L[0.28-1.28mg/dL])。她接受了口服抗坏血酸治疗。补充剂治疗 4 周后,客观的皮肤表现得到改善,6 周后,维生素 C 水平再次检测为 102μmol/L(1.15mg/dL)。据我们所知,这是首例青少年女性神经性厌食症和坏血病皮肤表现的病例,经口服维生素 C 治疗后得到缓解。