The Centre for Biomedical and Chemical Sciences, School of Science, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand.
Nottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham Biodiscovery Institute, Nottingham, UK.
Trends Cancer. 2020 Jul;6(7):543-547. doi: 10.1016/j.trecan.2020.03.006. Epub 2020 Apr 11.
Sperm-associated Antigen 5 (SPAG5) is a mitotic spindle protein. Recent studies have found that it is overexpressed in many human cancers and functions as an oncogene. Here, we summarize the current underlying mechanisms for its oncogenic roles in regulating cellular behaviors of cancer cells and discuss the possibility of targeting SPAG5 for cancer treatment.
精子相关抗原 5（SPAG5）是一种有丝分裂纺锤体蛋白。最近的研究发现，它在许多人类癌症中过度表达，并作为癌基因发挥作用。在这里，我们总结了其在调节癌细胞细胞行为中的致癌作用的当前潜在机制，并讨论了针对 SPAG5 进行癌症治疗的可能性。
