Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
RNA Bioscience Initiative, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Traffic. 2020 Jun;21(6):404-418. doi: 10.1111/tra.12730. Epub 2020 Apr 29.
Essentially all cells contain a variety of spatially restricted regions that are important for carrying out specialized functions. Often, these regions contain specialized transcriptomes that facilitate these functions by providing transcripts for localized translation. These transcripts play a functional role in maintaining cell physiology by enabling a quick response to changes in the cellular environment. Here, we review how RNA molecules are trafficked within cells, with a focus on the subcellular locations to which they are trafficked, mechanisms that regulate their transport and clinical disorders associated with misregulation of the process.
基本上所有的细胞都含有各种对执行特定功能很重要的空间受限区域。这些区域通常包含专门的转录组，通过为局部翻译提供转录本来促进这些功能。这些转录本通过使细胞对细胞环境的变化做出快速反应，在维持细胞生理学方面发挥着功能作用。在这里，我们回顾了 RNA 分子在细胞内的运输方式，重点介绍了它们被运输到的亚细胞位置、调节它们运输的机制以及与该过程调节失常相关的临床疾病。
