Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Alzheimers Dement. 2020 May;16(5):726-733. doi: 10.1002/alz.12076. Epub 2020 Apr 14.
Delirium is an acute disorder of attention and cognition. It occurs across the life span, yet it is particularly common among older adults, and is closely linked with underlying neurocognitive disorders. Evidence is mounting that intervening on delirium may represent an important opportunity for delaying the onset or progression of dementia. To accelerate the current understanding of delirium, the Network for Investigation of Delirium: Unifying Scientists (NIDUS) held a conference "Advancing Delirium Research: A Scientific Think Tank" in June 2019. This White Paper encompasses the major knowledge and research gaps identified at the conference: advancing delirium definition and measurement, understanding delirium pathophysiology, and prevention and treatment of delirium. A roadmap of research priorities is proposed to advance the field in a systematic, interdisciplinary, and coordinated fashion. A call is made for an international consortium and biobank targeted to delirium, as well as a public health campaign to advance the field.
谵妄是一种急性注意力和认知障碍。它发生在整个生命周期中，但在老年人中尤为常见，并且与潜在的神经认知障碍密切相关。有越来越多的证据表明，干预谵妄可能是延迟痴呆发病或进展的重要机会。为了加速对谵妄的当前理解，谵妄调查网络：统一科学家（NIDUS）于 2019 年 6 月举行了一次“推进谵妄研究：科学智囊团”会议。本白皮书涵盖了会议确定的主要知识和研究差距：推进谵妄定义和测量、了解谵妄病理生理学、以及预防和治疗谵妄。提出了研究重点的路线图，以系统、跨学科和协调的方式推进该领域。呼吁成立一个针对谵妄的国际财团和生物库，并开展一项促进该领域发展的公共卫生运动。
