Weiss Shennan A, Song Inkyung, Leng Mei, Pastore Tomás, Slezak Diego, Waldman Zachary, Orosz Iren, Gorniak Richard, Donmez Mustafa, Sharan Ashwini, Wu Chengyuan, Fried Itzhak, Sperling Michael R, Bragin Anatol, Engel Jerome, Nir Yuval, Staba Richard
Department of Neurology and Neuroscience, Thomas Jefferson University, Philadelphia, PA, United States.
Department of Medicine, Statistics Core, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Front Neurol. 2020 Mar 24;11:174. doi: 10.3389/fneur.2020.00174. eCollection 2020.
Ripple oscillations (80-200 Hz) in the normal hippocampus are involved in memory consolidation during rest and sleep. In the epileptic brain, increased ripple and fast ripple (200-600 Hz) rates serve as a biomarker of epileptogenic brain. We report that both ripples and fast ripples exhibit a preferred phase angle of coupling with the trough-peak (or On-Off) state transition of the sleep slow wave in the hippocampal seizure onset zone (SOZ). Ripples on slow waves in the hippocampal SOZ also had a lower power, greater spectral frequency, and shorter duration than those in the non-SOZ. Slow waves in the mesial temporal lobe modulated the baseline firing rate of excitatory neurons, but did not significantly influence the increased firing rate associated with ripples. In summary, pathological ripples and fast ripples occur preferentially during the On-Off state transition of the slow wave in the epileptogenic hippocampus, and ripples do not require the increased recruitment of excitatory neurons.
正常海马体中的涟漪振荡（80 - 200赫兹）参与休息和睡眠期间的记忆巩固。在癫痫大脑中，涟漪和快速涟漪（200 - 600赫兹）频率增加是致痫性脑的生物标志物。我们报告，在海马癫痫发作起始区（SOZ），涟漪和快速涟漪均表现出与睡眠慢波的波谷 - 波峰（或开 - 关）状态转换的优先耦合相位角。海马SOZ慢波上的涟漪在功率、频谱频率和持续时间方面也低于非SOZ区域的涟漪。内侧颞叶的慢波调节兴奋性神经元的基线放电率，但对与涟漪相关的放电率增加没有显著影响。总之，病理性涟漪和快速涟漪优先出现在致痫性海马体慢波的开 - 关状态转换期间，并且涟漪不需要增加兴奋性神经元的募集。
