Ramacci M T, De Rossi M, Lucreziotti M R, Mione M C, Amenta F
Biological Research Laboratories, Sigma Tau S.p.A., Pomezia, Rome, Italy.
Drugs Exp Clin Res. 1988;14(9):593-601.
The effects of long-term treatment (11 months) with acetyl-L-carnitine (75 mg/kg daily) on the morphology of brain and optic nerve was studied in 16 senescent (22-month-old) Wistar rats (nine untreated, seven treated). Five young rats (aged 3 months) were used for comparison. Senescence was found to cause a structural disorganization of cerebral cortex, hippocampus and cerebellar cortex, and a decrease in the volume densities of the pyramidal neurons of layers 2 and 5 of the prefrontal cortex. An impaired myelination of the pyramidal tract and of the optic nerve was also observed. Besides improving the structural organization of the cerebral areas under study, treatment with acetyl-L-carnitine increased the volume densities of pyramidal neurons of the prefrontal cortex layers under observation. It must be added that myelination of the pyramidal tract and optic nerve was found to be less impaired after acetyl-L-carnitine administration.
在16只衰老（22月龄）的Wistar大鼠（9只未治疗，7只接受治疗）中研究了长期（11个月）给予乙酰-L-肉碱（每日75毫克/千克）对大脑和视神经形态的影响。使用5只年轻大鼠（3月龄）作为对照。发现衰老会导致大脑皮层、海马体和小脑皮层的结构紊乱，以及前额叶皮层第2层和第5层锥体细胞的体积密度降低。还观察到锥体束和视神经的髓鞘形成受损。除了改善所研究脑区的结构组织外，乙酰-L-肉碱治疗还增加了观察到的前额叶皮层各层锥体细胞的体积密度。必须补充的是，给予乙酰-L-肉碱后，发现锥体束和视神经的髓鞘形成受损程度较轻。
