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Protocol for Prevention and Control of COVID-19 (Edition 6).新型冠状病毒肺炎防控方案(第六版)
China CDC Wkly. 2020 May 8;2(19):321-326. doi: 10.46234/ccdcw2020.082.
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ACE2 Expression in Kidney and Testis May Cause Kidney and Testis Infection in COVID-19 Patients.血管紧张素转换酶2(ACE2)在肾脏和睾丸中的表达可能导致COVID-19患者的肾脏和睾丸感染。
Front Med (Lausanne). 2021 Jan 13;7:563893. doi: 10.3389/fmed.2020.563893. eCollection 2020.
3
Innate Immune Signaling and Proteolytic Pathways in the Resolution or Exacerbation of SARS-CoV-2 in Covid-19: Key Therapeutic Targets?固有免疫信号和蛋白水解途径在新冠病毒 2 型(SARS-CoV-2)引起的新冠肺炎(Covid-19)中的转归或恶化:关键治疗靶点?
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Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues.SARS-CoV-2 细胞受体基因 ACE2 在多种人类组织中的表达。
Infect Dis Poverty. 2020 Apr 28;9(1):45. doi: 10.1186/s40249-020-00662-x.
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Urgent avenues in the treatment of COVID-19: Targeting downstream inflammation to prevent catastrophic syndrome.2019冠状病毒病治疗的紧急途径:针对下游炎症以预防灾难性综合征。
Joint Bone Spine. 2020 May;87(3):191-193. doi: 10.1016/j.jbspin.2020.03.011.
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Liver Int. 2020 Jun;40(6):1321-1326. doi: 10.1111/liv.14449. Epub 2020 Apr 12.
7
Liver injury in COVID-19: management and challenges.新型冠状病毒肺炎中的肝损伤:管理与挑战
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Lancet Respir Med. 2020 Apr;8(4):420-422. doi: 10.1016/S2213-2600(20)30076-X. Epub 2020 Feb 18.
9
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study.中国武汉 99 例 2019 年新型冠状病毒肺炎患者的流行病学和临床特征:描述性研究。
Lancet. 2020 Feb 15;395(10223):507-513. doi: 10.1016/S0140-6736(20)30211-7. Epub 2020 Jan 30.
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分析 92 例新冠肺炎死亡患者。

Analysis of 92 deceased patients with COVID-19.

机构信息

Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan, China.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.

出版信息

J Med Virol. 2020 Nov;92(11):2511-2515. doi: 10.1002/jmv.25891. Epub 2020 Aug 21.

DOI:10.1002/jmv.25891
PMID:32293741
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7262332/
Abstract

This retrospective study aimed to analyze the clinical characteristics and complications in death cases with novel coronavirus disease-19 (COVID-19). We collected the medical records of 92 patients with COVID-19, who died in the time period ranging from 6 January 2020 to 25 February 2020, in Renmin Hospital of Wuhan University and summarized the clinical characteristics of complications. There were 91 death cases in which different complications were developed, including acute respiratory distress syndrome (ARDS) (73/91), myocardial injury (31/91), liver injury (15/91), renal insufficiency (14/91), multiple organ dysfunction syndrome (MODS) (14/91), and pneumothorax (1/91). Among these patients, 83 patients had at least one complication. However, one patient who died of recurrent gastrointestinal bleeding was not directly linked to COVID-19. The main complications of deceased patients with COVID-19 were ARDS, myocardial injury, liver injury, renal insufficiency, and MODS.

摘要

这项回顾性研究旨在分析新型冠状病毒病(COVID-19)死亡病例的临床特征和并发症。我们收集了 2020 年 1 月 6 日至 2 月 25 日期间在武汉大学人民医院因 COVID-19 死亡的 92 例患者的病历,并总结了并发症的临床特征。91 例死亡病例出现了不同的并发症,包括急性呼吸窘迫综合征(ARDS)(73/91)、心肌损伤(31/91)、肝损伤(15/91)、肾功能不全(14/91)、多器官功能障碍综合征(MODS)(14/91)和气胸(1/91)。这些患者中,83 例至少有一种并发症。然而,1 例死于复发性胃肠道出血的患者与 COVID-19 无关。COVID-19 死亡患者的主要并发症为 ARDS、心肌损伤、肝损伤、肾功能不全和 MODS。