Pharmaceutical Science Department, College of Pharmacy, Princess Nourah Bint Abdul Rahman University, Riyadh, Saudi Arabia.
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Environ Toxicol. 2020 Sep;35(9):952-960. doi: 10.1002/tox.22931. Epub 2020 Apr 15.
Silver nanoparticles (AgNPs), one of the most well-known nanomaterials, are regularly utilized in everyday consumer products. The present study aimed to investigate the testicular toxicity and oxidative stress by AgNPs and the therapeutic role of the rocket seeds (Eruca sativa) in treatments. Forty male Wistar rats were divided into four equivalent groups (group 1, control; group 2, rocket seeds extract [RS]; group 3, AgNPs; group 4, AgNPs+RS). Our results showed that AgNPs induced a significant decrease in serum total testosterone, FSH (follicle-animating hormone), prolactin and LH (luteinizing hormone), testicular glutathione (GSH), superoxide dismutase (SOD), and glutathione S-transferase (GST). In contrast, a significant increase in testicular DNA, injury, testicular thiobarbituric acid, proliferating cell nuclear antigen, and tumor necrosis factor-α (TNFα) expressions after treatments with AgNPs when contrasted with the control group. Treatments of AgNPs with rocket seeds extract (AgNPs+RS) improved testicular functions and structure. Rocket seeds extract might offer benefits against the toxic nature of AgNPs.
银纳米粒子（AgNPs）是最著名的纳米材料之一，经常用于日常消费品。本研究旨在探讨 AgNPs 的睾丸毒性和氧化应激作用，以及火箭种子（Eruca sativa）在治疗中的治疗作用。将 40 只雄性 Wistar 大鼠分为四组（第 1 组，对照组；第 2 组，火箭种子提取物[RS]；第 3 组，AgNPs；第 4 组，AgNPs+RS）。我们的结果表明，AgNPs 导致血清总睾酮、卵泡刺激素（FSH）、催乳素和黄体生成素（LH）、睾丸谷胱甘肽（GSH）、超氧化物歧化酶（SOD）和谷胱甘肽 S-转移酶（GST）显著降低。相比之下，与对照组相比，AgNPs 处理后睾丸 DNA、损伤、睾丸硫代巴比妥酸、增殖细胞核抗原和肿瘤坏死因子-α（TNFα）的表达显著增加。AgNPs 与火箭种子提取物（AgNPs+RS）的联合处理改善了睾丸功能和结构。火箭种子提取物可能对 AgNPs 的毒性具有有益作用。
