向家兔腹内侧下丘脑微量注射皮质酮对肝脏乙酸代谢的影响。

Influence of microinjection of corticosterone into ventromedial hypothalamus on hepatic acetate metabolism in rabbits.

作者信息

Seto K, Saito H, Kaba H, Ohri A, Tanaka J, Otsuka K, Ozawa T, Kawakami M

机构信息

First Department of Physiology, Kochi Medical School, Nankoku, Japan.

出版信息

Exp Clin Endocrinol. 1988 Sep;92(1):111-4. doi: 10.1055/s-0029-1210789.

DOI:10.1055/s-0029-1210789

PMID:3229443

Abstract

Corticosterone was injected into the ventromedial hypothalamus (VMH) of rabbits, and changes in hepatic acetate metabolism were studied. The microinjection of corticosterone with seasame oil into the VMH of intact rabbits increased the rates of 14C transfer from 14C-1-acetate into CO2, glucose, ketone bodies, triglyceride, free cholesterol, free fatty acids and phospholipids but decreased those of 14C transfer into cholesterol ester. However, corticosterone injected into the VMH of rabbits with VMH lesions or the parietal cortex of intact rabbits was without effect on the hepatic acetate metabolism. From these results it might be suggested that the VMH is an integral part of the corticosterone-sensitive brain regulator system in the hepatic acetate metabolism.

摘要

将皮质酮注射到兔的腹内侧下丘脑（VMH）中，并研究肝脏乙酸代谢的变化。将皮质酮与芝麻油微量注射到完整兔的VMH中，可提高14C从14C-1-乙酸转移到二氧化碳、葡萄糖、酮体、甘油三酯、游离胆固醇、游离脂肪酸和磷脂中的速率，但降低14C转移到胆固醇酯中的速率。然而，将皮质酮注射到VMH损伤的兔的VMH或完整兔的顶叶皮质中，对肝脏乙酸代谢没有影响。从这些结果可以推测，VMH是肝脏乙酸代谢中皮质酮敏感脑调节系统的一个组成部分。