向兔杏仁核微量注射胰岛素对兔肝切片中乙酸代谢的影响。

Influence of microinjection of insulin into amygdala on acetate metabolism in liver slices of rabbit.

作者信息

Seto K, Saito H, Edashige N, Kawakami T, Yoshimatsu K, Horiuchi C, Kawakami M

出版信息

Exp Clin Endocrinol. 1985 Dec;86(2):233-6. doi: 10.1055/s-0029-1210491.

Abstract

Insulin was injected directly into the medial amygdala (AMYG) of rabbits, and changes in hepatic acetate metabolism were studied. The injection of 50 microU insulin into the AMYG decreased the rates of 14C transfer from 14C-1-acetate into CO2 and cholesterol ester, and increased those into free cholesterol and phospholipids. But after insulin injection into parietal cortex of intact rabbits and into the AMYG of rabbits with lesions of stria terminalis (ST), hepatic acetate metabolism did not differ from that of the control rabbits, which received saline injection into the same brain regions. These observations support the hypothesis that the AMYG is a part of insulin-sensitive brain regulator system in the hepatic acetate metabolism.

摘要

将胰岛素直接注射到兔的内侧杏仁核（AMYG）中，并研究肝脏乙酸代谢的变化。向AMYG注射50微单位胰岛素可降低14C从14C-1-乙酸向二氧化碳和胆固醇酯的转移速率，并增加其向游离胆固醇和磷脂的转移速率。但是，在向完整兔的顶叶皮层以及向终纹床核（ST）损伤的兔的AMYG注射胰岛素后，肝脏乙酸代谢与对照兔（在相同脑区接受盐水注射）并无差异。这些观察结果支持了以下假说：AMYG是肝脏乙酸代谢中胰岛素敏感脑调节系统的一部分。