向家兔腹内侧下丘脑微量注射胰高血糖素对肝脏切片中乙酸代谢的影响。

Influence of microinjection of glucagon into ventromedial hypothalamus on acetate metabolism in liver slices of rabbit.

作者信息

Seto K, Saito H, Kaba H, Tanaka J, Takeshima Y, Edashige N, Kitaoka K, Kawakami M

出版信息

Exp Clin Endocrinol. 1987 Mar;89(1):105-8. doi: 10.1055/s-0029-1210634.

Abstract

Glucagon was injected directly into the ventromedial hypothalamic nuclei (VMH) of rabbits, and changes in hepatic acetate metabolism were studied. The injection of 3 ng glucagon into the VMH of intact rabbits increased the rates of 14C transfer from 14C-1-acetate into CO2, glucose and ketone bodies but decreased those into cholesterol ester, triglyceride, free cholesterol, free fatty acids and phospholipids. However, after glucagon injection into the VMH of rabbits with VMH lesions and the parietal cortex of intact rabbits, hepatic acetate metabolism did not differ from that of the control rabbits, which received saline injection into the same brain regions. These observations support the hypothesis that the VMH are parts of a glucagon-sensitive brain regulator system in the hepatic acetate metabolism.

摘要

将胰高血糖素直接注入家兔腹内侧下丘脑核（VMH），并研究肝脏乙酸代谢的变化。向完整家兔的VMH注射3纳克胰高血糖素，可提高14C从14C-1-乙酸向二氧化碳、葡萄糖和酮体的转移速率，但降低其向胆固醇酯、甘油三酯、游离胆固醇、游离脂肪酸和磷脂的转移速率。然而，向VMH损伤的家兔VMH以及完整家兔的顶叶皮质注射胰高血糖素后，肝脏乙酸代谢与向相同脑区注射生理盐水的对照家兔并无差异。这些观察结果支持以下假说：VMH是肝脏乙酸代谢中对胰高血糖素敏感的脑调节系统的组成部分。