Ethanol induced cardiomyopathy--role of periodic fasting.

The periodic fasting in presence of continuous ethanol feeding produces pronounced morphological changes in the myocardium and its organelles of the rats. This effect of ethanol could be directly related to the sensitive state of myocardium to the former, specially when ethanol becomes an important source of energy. This is proved further by intraperitoneal injection of 40% ethanol, when profound mitochondrial morphological changes, even leading to formation of lysosome like structures, are evident in the myocardium. The study has stressed the pronounced direct effect of ethanol and its metabolites in the development of morphological changes of the myocardium.