巴西乳糜泻女性的生殖方面

REPRODUCTIVE ASPECTS IN BRAZILIAN CELIAC WOMEN.

作者信息

Kotze Lorete Maria da Silva, Mallmann Andyara, Miecznikowski Rebeca C, Chrisostomo Kadija Rahal, Kotze Luiz Roberto, Nisihara Renato

机构信息

Universidade Federal do Paraná, Hospital de Clínicas, Curitiba, PR, Brasil.

Faculdade Evangélica Mackenzie do Paraná, Departamento de Medicina, Curitiba, PR, Brasil.

出版信息

Arq Gastroenterol. 2020 Jan-Mar;57(1):107-109. doi: 10.1590/S0004-2803.202000000-18.

DOI:10.1590/S0004-2803.202000000-18

PMID:32294744

Abstract

BACKGROUND

Celiac disease (CD) is a chronic enteropathy in response to ingestion of gluten. CD was associated with gynecological disorders.

OBJECTIVE

In this retrospective study, we aimed to investigate the age of menarche, age of menopause, number of pregnancies and abortions in Brazilian celiac patients.

METHODS

We studied 214 women diagnosed with CD and as control group 286 women were investigated.

RESULTS

Regarding the mean age of menarche, a significant difference was found (12.6±1.40 in CD and 12.8±1.22 years in healthy group; P=0.04). Regarding abortions, in CD women 38/214 (17.8%) and 28/286 (9.8%) in the control group reported abortion (P=0.0092, OR:1.98; CI95%=1.1- 3.3). There was no significant difference in the mean age of menopause nor number of pregnancies per woman.

CONCLUSION

In this study, we found that celiac women had a higher mean age of menarche and higher risk of spontaneous abortions.

摘要

背景

乳糜泻（CD）是一种因摄入麸质而引发的慢性肠病。乳糜泻与妇科疾病有关。

目的

在这项回顾性研究中，我们旨在调查巴西乳糜泻患者的初潮年龄、绝经年龄、怀孕次数和流产次数。

方法

我们研究了214名被诊断为乳糜泻的女性，并对286名女性作为对照组进行了调查。

结果

关于初潮的平均年龄，发现存在显著差异（乳糜泻组为12.6±1.40岁，健康组为12.8±1.22岁；P = 0.04）。关于流产，乳糜泻组女性中有38/214（17.8%）报告有流产，对照组中有28/286（9.8%）报告有流产（P = 0.0092，OR：1.98；95%CI = 1.1 - 3.3）。绝经的平均年龄和每位女性的怀孕次数没有显著差异。