斯洛文尼亚乳糜泻患者的月经初潮并未延迟。
Onset of menarche is not delayed in Slovenian patients with celiac disease.
作者信息
Mičetić-Turk Dušanka, Vlaisavljević Veljko, Turk Eva, Pogačar Maja Šikić
机构信息
1 Department of Pediatrics, Faculty of Medicine, University of Maribor, Maribor, Slovenia.
2 IVF Adria Consulting, Maribor, Slovenia.
出版信息
J Int Med Res. 2019 Feb;47(2):815-822. doi: 10.1177/0300060518812623. Epub 2018 Nov 26.
OBJECTIVE
Celiac disease (CD) is an autoimmune disorder associated with numerous health problems, including reproductive disorders. This study was performed to analyze the association between CD and the menstrual cycle in a group of patients with CD and compare these patients' characteristics with those of healthy women.
METHODS
The study included 145 patients with CD (age, 15-51 years) and 162 healthy women (age, 18-55 years). Age at menarche and characteristics of the menstrual cycle were obtained by an anonymous questionnaire developed for the study.
RESULTS
The age at onset of menarche was 12 to 14 years in 72.9% of the patients with CD and 77.3% of the healthy controls. For most patients (74.2%), the length of the menstrual cycle was around 27 to 28 days with 4 to 5 days of bleeding. Furthermore, 8.4% of patients versus 5.9% of controls experienced bleeding between cycles.
CONCLUSIONS
Our results suggest that in Slovenia, the age at menarche in patients with CD is 12.7 years, which is comparable with that in healthy women. We conclude that CD (treated or untreated) may not be associated with late menarche.
目的
乳糜泻（CD）是一种与众多健康问题相关的自身免疫性疾病，包括生殖系统紊乱。本研究旨在分析一组乳糜泻患者中CD与月经周期之间的关联，并将这些患者的特征与健康女性的特征进行比较。
方法
该研究纳入了145例乳糜泻患者（年龄15 - 51岁）和162例健康女性（年龄18 - 55岁）。月经初潮年龄和月经周期特征通过为本研究编制的匿名问卷获取。
结果
72.9%的乳糜泻患者和77.3%的健康对照者月经初潮年龄为12至14岁。对于大多数患者（74.2%），月经周期长度约为27至28天，出血4至5天。此外，8.4%的患者与5.9%的对照者在月经周期之间出现出血情况。
结论
我们的结果表明，在斯洛文尼亚，乳糜泻患者的月经初潮年龄为12.7岁，与健康女性相当。我们得出结论，CD（无论是否接受治疗）可能与月经初潮延迟无关。
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