Liu Y H, Lu J Y, Liu W H, Ma Y, Cao L, Li K B, Li T G, Zhang Z B, Yang Z C
Guangzhou Municipal Center for Disease Control and Prevention, Guangzhou 510440, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2020 Mar 10;41(3):358-362. doi: 10.3760/cma.j.issn.0254-6450.2020.03.015.
To investigate the epidemiological and clinical characteristics of a case infected with avian influenza A (H5N6) virus associated with exposure to aerosol and provide evidence for the prevention and control of human infection with avian influenza virus. Epidemiological investigation was conducted to identify the history of exposure, infection route, and disease progression. Real-time fluorescent quantitative RT-PCR was used to test the samples collected from the case, close contacts, environment and poultry market. The case had no history of exposure to live poultry and poultry market. But before the onset the case had a history of exposure to the live poultry placed in a car with doors and windows closed. The samples collected from the case's lower respiratory tract and the remaining frozen chicken meat were all influenza A (H5N6) virus positive. The source of infection was the live poultry, and the infection route might be the exposure to aerosol in a car with doors and windows closed, where the poultry were temporarily stored. It is necessary to promote centralized poultry slaughtering, cold chain distribution and fresh poultry sale, as well as strengthen health education and establish the concept of consuming fresh poultry.
调查1例与气溶胶暴露相关的甲型H5N6禽流感病毒感染病例的流行病学及临床特征，为防控人感染禽流感病毒提供依据。开展流行病学调查以明确暴露史、感染途径及疾病进展情况。采用实时荧光定量RT-PCR检测病例、密切接触者、环境及家禽市场采集的样本。该病例无活禽及家禽市场暴露史，但发病前有在门窗紧闭的车内接触活禽的历史。病例下呼吸道及剩余冻鸡肉样本甲型H5N6禽流感病毒核酸均为阳性。传染源为活禽，感染途径可能是在门窗紧闭的车内临时存放家禽处暴露于气溶胶。需推进家禽集中屠宰、冷链配送和生鲜上市，同时加强健康教育，树立生鲜家禽消费观念。
