Hangzhou Center for Disease Control and Prevention, Zhejiang, People's Republic of China.
Shangcheng District Center for Disease Control and Prevention, Zhejiang, People's Republic of China.
Emerg Microbes Infect. 2022 Dec;11(1):807-810. doi: 10.1080/22221751.2022.2048971.
Exposure to poultry in live poultry markets is strongly associated with human infection with avian influenza virus. To effectively prevent the transmission of viruses from live poultry to humans, people have been forced to change their living habits from purchasing live poultry for consumption to purchasing freshly slaughtered poultry after the permanent closure of live poultry markets in China. In this study, we reported a case of human infection by the H5N6 virus in Hangzhou after exposure to a freshly slaughtered chicken, defying the traditional hypothesis that human infection requires a history of exposure to live poultry and indicating a novel route of infection. Rapid genomic characterization of H5N6 influenza A variants from the patient and the associated environment suggested that these viral variants were of avian origin, belonged to clade 2.3.4.4b H5 and were adapting to the human host after infection. Comparative analysis of the local H5N6 genomes showed that viral contamination in the associated environment and the poultry market was complex. Considering this case of H5N6 infection, conducting surveillance for any possible new avian influenza virus reassortment spillover to humans or other animal species is critical, and awareness of the risk of exposure to possible viral variants from infected slaughtered poultry or the associated environment must be seriously improved. We reported the first case of human infection with avian-origin influenza A (H5N6) virus in Zhejiang Province, southeastern China.Rapid genomic characterization of H5N6 influenza A variants from a patient and the associated environment suggested that these viral variants were of avian origin and were adapting to the human host after infection.Comparative analysis of the H5N6 genomes showed that viral contamination in the associated environment and poultry market was complex.Considering this case of H5N6 infection, the risk of exposure to possible viral variants from infected slaughtered poultry or the associated environment must be seriously considered.
接触活禽市场中的禽类与人类感染禽流感病毒密切相关。为了有效防止病毒从活禽向人类传播，在中国永久关闭活禽市场后，人们被迫改变生活习惯，由购买活禽改为购买新鲜宰杀的家禽。在本研究中，我们报告了一例在中国杭州发生的人感染 H5N6 病毒病例，该病例是由于接触新鲜宰杀的鸡引起的，这一结果挑战了人类感染需要有接触活禽的历史这一传统假设，并提示了一种新的感染途径。对患者和相关环境中 H5N6 流感 A 变异株的快速基因组特征分析表明，这些病毒变异株源自禽类，属于 2.3.4.4b 分支的 H5，感染后适应了人类宿主。对当地 H5N6 基因组的比较分析表明，相关环境和禽类市场中的病毒污染情况复杂。鉴于这例 H5N6 感染病例，必须对任何可能的新禽流感病毒重组溢出到人类或其他动物物种的情况进行监测，同时必须认真提高对接触感染宰杀家禽或相关环境中可能的病毒变异株的风险意识。我们报告了中国东南部浙江省首例人感染禽流感 A（H5N6）病毒病例。对患者和相关环境中 H5N6 流感 A 变异株的快速基因组特征分析表明，这些病毒变异株源自禽类，感染后适应了人类宿主。对 H5N6 基因组的比较分析表明，相关环境和禽类市场中的病毒污染情况复杂。鉴于这例 H5N6 感染病例，必须认真考虑接触感染宰杀家禽或相关环境中可能的病毒变异株的风险。
