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巴旦木壳提取物最具细胞毒性的部分在乳腺癌的体外和体内抗癌活性。

In Vitro and In Vivo Anticancer Activity of the Most Cytotoxic Fraction of Pistachio Hull Extract in Breast Cancer.

机构信息

Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia.

Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.

出版信息

Molecules. 2020 Apr 13;25(8):1776. doi: 10.3390/molecules25081776.

DOI:10.3390/molecules25081776
PMID:32295069
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7221789/
Abstract

Pistacia () hulls (PV) is a health product that has been determined to contain bioactive phytochemicals which have fundamental importance for biomedical use. In this study, PV ethyl acetate extraction (PV-EA) fractions were evaluated with the use of an MTT assay to find the most cytotoxic fraction, which was found to be F13b1/PV-EA. After that, HPTLC was used for identify the most active compounds. The antioxidant activity was analyzed with DPPH and ABTS tests. Apoptosis induction in MCF-7 cells by F13b1/PV-EA was validated via flow cytometry analysis and a distinctive nuclear staining method. The representation of genes like , , , , and was assessed via a reverse transcription (RT_PCR) method. Inhabitation of Tubo breast cancer cell development was examined in the BALB-neuT mouse with histopathology observations. The most abundant active components available in our extract were gallic acid and the flavonoid quercetin. The F13b1/PV-EA has antiradical activity evidence by its inhibition of ABTS and DPPH free radicals. F13b1/PV-EA displayed against MCF-7 a suppressive effect with an IC value of 15.2 ± 1.35 µg/mL. Also, the expression of , , , and increased and the expression of decreased. F13b1/PV-EA dose-dependently inhibited tumor development in cancer-induced mice. Thus, this finding introduces F13b1/PV-EA as an effectual apoptosis and antitumor active agent against breast cancer.

摘要

乳香树（Pistacia）种皮（PV）是一种保健品，已被确定含有具有重要生物医学用途的生物活性植物化学成分。在这项研究中，使用 MTT 测定法评估了 PV 乙酸乙酯提取物（PV-EA）的馏分，以找到最具细胞毒性的馏分，结果发现是 F13b1/PV-EA。之后，使用 HPTLC 来鉴定最活跃的化合物。抗氧化活性通过 DPPH 和 ABTS 测试进行分析。通过流式细胞术分析和独特的核染色方法验证 F13b1/PV-EA 对 MCF-7 细胞的凋亡诱导作用。通过逆转录（RT-PCR）方法评估基因如、、、、和的表达。通过组织病理学观察，在 BALB-neuT 小鼠中检查 F13b1/PV-EA 对 Tubo 乳腺癌细胞发育的抑制作用。我们的提取物中含量最丰富的活性成分是没食子酸和类黄酮槲皮素。F13b1/PV-EA 具有抗自由基活性，可通过抑制 ABTS 和 DPPH 自由基得到证明。F13b1/PV-EA 对 MCF-7 表现出抑制作用，IC 值为 15.2±1.35μg/mL。此外，表达、、、和增加，而表达减少。F13b1/PV-EA 剂量依赖性地抑制了癌症诱导小鼠中的肿瘤发展。因此，这一发现表明 F13b1/PV-EA 是一种有效的针对乳腺癌的凋亡和抗肿瘤活性药物。

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