Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, South Korea.
Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Gynecol Endocrinol. 2020 Jul;36(7):636-640. doi: 10.1080/09513590.2020.1753183. Epub 2020 Apr 16.
Both environmental and genetic factors interact and play a critical role in the pathogenesis of endometriosis. We analyzed the plasma levels of 12 polychlorinated biphenyl (PCB) congeners with genetic polymorphisms of glutathione-S-transferase M1 (GSTM1), glutathione-S-transferase T1 (GSTT1), and aryl hydrocarbon receptor repressor (AhRR) codon 185. Total sum of the 12 congeners was significantly higher in the controls compared with endometriosis group. Women without C/C genotype in AhRR codon 185 had a significantly increased risk of endometriosis compared with those with C/C genotype. Total sum of the 12 congeners was significantly higher in women without C/C genotype compared with those with C/C genotype. Adjusting for age and AhRR codon 185 genotype, there was no significant association between exposure to PCBs and the risk of endometriosis. These findings suggest a possible presence of gene-environment interaction, however, we could not see any clear association between exposure to PCBs and the risk of endometriosis.
环境和遗传因素相互作用，在子宫内膜异位症的发病机制中起着关键作用。我们分析了具有谷胱甘肽 S-转移酶 M1（GSTM1）、谷胱甘肽 S-转移酶 T1（GSTT1）和芳香烃受体阻遏物（AhRR）密码子 185 遗传多态性的 12 种多氯联苯（PCB）同系物的血浆水平。与子宫内膜异位症组相比，对照组中这 12 种同系物的总浓度明显更高。与 AhRR 密码子 185 中 C/C 基因型的女性相比，没有 C/C 基因型的女性患子宫内膜异位症的风险显著增加。与 AhRR 密码子 185 中 C/C 基因型的女性相比，没有 C/C 基因型的女性中这 12 种同系物的总浓度明显更高。在调整年龄和 AhRR 密码子 185 基因型后，接触多氯联苯与子宫内膜异位症的风险之间没有显著关联。这些发现表明可能存在基因-环境相互作用，但我们没有看到接触多氯联苯与子宫内膜异位症风险之间存在任何明确的关联。
