Michna H, Hartmann G
Institut für Anatomie, Medizinische Universität zu Lübeck, BRD.
Gegenbaurs Morphol Jahrb. 1988;134(6):903-12.
The aim of the present experimental study is to investigate the functional behaviour of cell nuclei in tendon tissue. For this purpose semithin sections of tendons excised from mice subjected to treadmill exercise are analysed quantitatively to establish the number of cell nuclei of tendinoblasts. The number of nuclei per volume unit of tendon tissue, nuclear size, and the behaviour of these parameters in relation to tendon calibre are determined functionally. Particular attention is given to the question--interesting both from the clinical point of view and with regard to sportsmedicine--whether the use of a synthetic androgen has any harmful effect on tendon tissue: According to the findings of the present study, a dramatic decrease in nuclear density is likely to be of pathogenetic relevance to the occurrence of collagen dysplasia.
本实验研究的目的是调查肌腱组织中细胞核的功能行为。为此，对从接受跑步机运动的小鼠身上切除的肌腱半薄切片进行定量分析，以确定成纤维细胞的细胞核数量。从功能上确定肌腱组织单位体积的细胞核数量、核大小以及这些参数与肌腱直径的关系。特别关注一个从临床角度和运动医学角度都很有趣的问题，即合成雄激素的使用是否对肌腱组织有任何有害影响：根据本研究的结果，核密度的显著降低可能与胶原蛋白发育异常的发生在发病机制上有关。
