Michna H
Int Orthop. 1987;11(2):157-62. doi: 10.1007/BF00266702.
The purpose of this study was to examine the effect of anabolic steroid hormones and exercise training on skeletal tendons. Female mice were exercised for 1 and 10 weeks in an endurance running programme on a treadmill. The altered ultrastructure of tendons caused by simultaneously administered anabolic steroid hormone was investigated by electron microscopy. A stereoscopic analysis of collagen fibrils was performed in order to reveal the changes in the architecture of tendons and to quantify the extent of possible injuries to their functional structure. The occurrence of tendon injuries was detected by the appearance of a collagen dysplasia. The morphometric analysis of the degree of the collagen dysplasia in the different experimental groups reveals that it becomes even more conspicuous in the tendons of the mice which were both exercised and given anabolic steroids. The overall picture and the architecture of the tendons provide tentative evidence that anabolic steroid hormones may induce tendon injuries, depending on the duration of treatment. The direct effect of anabolic steroids on tendons has to be taken into account when considering the clinical disorders of tendons and ligaments which occur in high-class athletes.
本研究的目的是探讨合成代谢类固醇激素和运动训练对骨骼肌腱的影响。雌性小鼠在跑步机上进行耐力跑步计划，持续1周和10周。通过电子显微镜研究同时给予合成代谢类固醇激素引起的肌腱超微结构改变。对胶原纤维进行立体分析，以揭示肌腱结构的变化，并量化其功能结构可能损伤的程度。通过胶原发育异常的出现来检测肌腱损伤的发生。对不同实验组胶原发育异常程度的形态计量分析表明，在既运动又给予合成代谢类固醇的小鼠的肌腱中，这种异常变得更加明显。肌腱的整体情况和结构提供了初步证据，表明合成代谢类固醇激素可能会根据治疗持续时间导致肌腱损伤。在考虑高级运动员中发生的肌腱和韧带临床疾病时，必须考虑合成代谢类固醇对肌腱的直接影响。
