Cho Hyunnho, Kim Kyong, Kim Nayeon, Woo Minji, Kim Hye Young
Division of Functional Food Research, Korea Food Research Institute, 245 Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do 55365 Korea.
Food Sci Biotechnol. 2019 Oct 14;29(4):579-584. doi: 10.1007/s10068-019-00688-4. eCollection 2020 Apr.
Propolis is known to have multiple biological and pharmacological properties including the regulation of energy homeostasis. Although phenolic compounds are considered to be the major active components in propolis, there is little information available about their mechanisms underlying the regulation of energy homeostasis. In this study, the effects of five phenolic compounds in propolis, chrysin, pinocembrin, galangin, pinobanksin, and caffeic acid phenethyl ester (CAPE) were evaluated on the activation of free fatty acid receptor 4 (FFA4), which are involved in the control of energy homeostasis by enhancing insulin signaling, increasing glucose uptake, and regulating adipogenesis. The results showed that three phenolic compounds exhibited the activation of FFA4, which were ranked in the order of pinocembrin, CAPE and pinobanksin in FFA4-expressing cells. These results suggest that some phenolic compounds in propolis, particularly pinocembrin, may affect the control of energy homeostasis via the activation of FFA4.
已知蜂胶具有多种生物学和药理学特性，包括对能量稳态的调节。尽管酚类化合物被认为是蜂胶中的主要活性成分，但关于它们调节能量稳态的潜在机制的信息却很少。在本研究中，评估了蜂胶中的五种酚类化合物白杨素、松属素、高良姜素、松脂素和咖啡酸苯乙酯（CAPE）对游离脂肪酸受体4（FFA4）激活的影响，FFA4通过增强胰岛素信号传导、增加葡萄糖摄取和调节脂肪生成参与能量稳态的控制。结果表明，三种酚类化合物表现出对FFA4的激活作用，在表达FFA4的细胞中，其激活作用顺序为松属素、CAPE和松脂素。这些结果表明，蜂胶中的一些酚类化合物，特别是松属素，可能通过激活FFA4影响能量稳态的控制。
