Tang Kai Dun, Vasani Sarju, Taheri Touraj, Walsh Laurence J, Hughes Brett G M, Kenny Lizbeth, Punyadeera Chamindie
Saliva and Liquid Biopsy Translational Research Team, The School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia.
Institute of Health and Biomedical Innovation, Translational Research Institute, Brisbane, QLD, Australia.
Front Oncol. 2020 Mar 31;10:408. doi: 10.3389/fonc.2020.00408. eCollection 2020.
Oropharyngeal cancer (OPC) caused by human papillomavirus (HPV) is a rising global concern. Early lesions are small and are often located in difficult to access areas (such as the crypts of the tonsils or base of tongue). Unlike cervical cancer, there is no standard or routine screening program for HPV-driven OPC. HPV DNA from OPC tumors may shed directly into saliva, and this can be used as a biomarker for early diagnosis. In this study, we report the first-ever clinically occult OPC in an asymptomatic patient discovered through a saliva test. This case relied upon serial measurements of HPV-16 DNA in saliva, which fell to undetectable levels following low morbidity, curative treatment.
由人乳头瘤病毒（HPV）引起的口咽癌（OPC）是一个日益引起全球关注的问题。早期病变较小，且常位于难以触及的区域（如扁桃体隐窝或舌根）。与宫颈癌不同，目前尚无针对HPV驱动的OPC的标准或常规筛查方案。OPC肿瘤中的HPV DNA可能直接排入唾液，这可作为早期诊断的生物标志物。在本研究中，我们报告了首例通过唾液检测发现的无症状临床隐匿性OPC病例。该病例依赖于对唾液中HPV-16 DNA的系列测量，在低发病率的根治性治疗后，其水平降至检测不到。
