Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research-Raebareli (NIPER-R), Bijnor-Sisendi Road, Sarojini Nagar, Near CRPF Base Camp, Lucknow-226002, U.P., India.
Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research-Raebareli (NIPER-R), Bijnor-Sisendi Road, Sarojini Nagar, Near CRPF Base Camp, Lucknow-226002, U.P., India.
Curr Top Med Chem. 2020;20(13):1169-1194. doi: 10.2174/1568026620666200416085330.
Flavonoids, a group of natural dietary polyphenols, are known for their beneficial effects on human health. By virtue of their various pharmacological effects, like anti-oxidative, antiinflammatory, anti-carcinogenic and neuroprotective effects, flavonoids have now become an important component of herbal supplements, pharmaceuticals, medicinals and cosmetics. There has been enormous literature supporting neuroprotective effect of flavonoids. Recently their efficacy in various neurodegenerative diseases, like Alzheimer's disease and Parkinson diseases, has received particular attention.
The mechanism of flavanoids neuroprotection might include antioxidant, antiapoptotic, antineuroinflammatory and modulation of various cellular and intracellular targets. In in-vivo systems, before reaching to brain, they have to cross barriers like extensive first pass metabolism, intestinal barrier and ultimately blood brain barrier. Different flavonoids have varied pharmacokinetic characteristics, which affect their pharmacodynamic profile. Therefore, brain accessibility of flavonoids is still debatable.
This review emphasized on current trends of research and development on flavonoids, especially in neurodegenerative diseases, possible challenges and strategies to encounter using novel drug delivery system.
Various flavonoids have elicited their therapeutic potential against neurodegenerative diseases, however by using nanotechnology and novel drug delivery systems, the bioavailability of favonoids could be enhanced.
This study bridges a significant opinion on medicinal chemistry, ethanopharmacology and new drug delivery research regarding use of flavonoids in management of neurodegeneration.
黄酮类化合物是一组天然的饮食多酚，因其对人类健康的有益作用而闻名。由于其具有多种药理作用，如抗氧化、抗炎、抗癌和神经保护作用，黄酮类化合物现已成为草药补充剂、药品、药物和化妆品的重要组成部分。有大量的文献支持黄酮类化合物的神经保护作用。最近，它们在各种神经退行性疾病（如阿尔茨海默病和帕金森病）中的疗效引起了特别关注。
黄酮类化合物的神经保护机制可能包括抗氧化、抗细胞凋亡、抗神经炎症和调节各种细胞内和细胞内靶点。在体内系统中，它们在到达大脑之前，必须穿过多种屏障，如广泛的首过代谢、肠道屏障和最终的血脑屏障。不同的黄酮类化合物具有不同的药代动力学特征，这影响了它们的药效学特征。因此，黄酮类化合物到达大脑的能力仍然存在争议。
本文重点介绍了黄酮类化合物在神经退行性疾病研究和开发方面的当前趋势，以及使用新型药物传递系统可能遇到的挑战和策略。
各种黄酮类化合物对神经退行性疾病表现出了治疗潜力，然而，通过使用纳米技术和新型药物传递系统，可以增强黄酮类化合物的生物利用度。
这项研究在药物化学、民族药理学和新药物传递研究方面就黄酮类化合物在神经退行性疾病管理中的应用提出了重要观点。
