神经退行性疾病的神经保护和神经修复黄酮类化合物的药理学评价。
A Pharmacological Appraisal of Neuroprotective and Neurorestorative Flavonoids Against Neurodegenerative Diseases.
机构信息
Department of Chinese Medicine, The University of Hong Kong Shenzhen Hospital, Shenzhen, China.
School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China.
出版信息
CNS Neurol Disord Drug Targets. 2019;18(2):103-114. doi: 10.2174/1871527317666181105093834.
BACKGROUND & OBJECTIVE: Alzheimer's disease (AD) and Parkinson's disease (PD) affect an increasing number of the elderly population worldwide. The existing treatments mainly improve the core symptoms of AD and PD in a temporary manner and cause alarming side effects. Naturally occurring flavonoids are well-documented for neuroprotective and neurorestorative effects against various neurodegenerative diseases. Thus, we analyzed the pharmacokinetics of eight potent natural products flavonoids for the druggability and discussed the neuroprotective and neurorestorative effects and the underlying mechanisms.
CONCLUSION
This review provides valuable clues for the development of novel therapeutics against neurodegenerative diseases.
背景与目的
阿尔茨海默病（AD）和帕金森病（PD）在全球范围内影响着越来越多的老年人群体。现有的治疗方法主要是暂时改善 AD 和 PD 的核心症状，并且会引起惊人的副作用。天然存在的类黄酮已被充分证明具有神经保护和神经修复作用，可以对抗各种神经退行性疾病。因此，我们分析了 8 种强效天然产物类黄酮的药代动力学，讨论了其神经保护和神经修复作用及其潜在机制。
结论
本综述为开发针对神经退行性疾病的新型治疗方法提供了有价值的线索。
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