Hindu College of Pharmacy, Sonepat, Haryana, India.
Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, Campus Vida, 15782 Santiago de Compostela, Spain.
Curr Top Med Chem. 2018;18(11):901-907. doi: 10.2174/1568026618666180711153416.
Neurodegenerative diseases are likely to emerge as the second cause of mortality in the world in coming years. NDDs cause tremendous financial burden on the healthcare system along with profound effect on families and patient. Disease-modifying treatment strategies with proven efficacy for these disorders are still lacking. Documentation proved that oxidative stress plays a leading role in the pathophysiology of many neurodegenerative disorders. Molecules with good antioxidant profile could be explored for the doctoring of these conditions. Neuroprotective effects of bioflavonoid morin have been well recognized in the literature. Morin being super antioxidant compound helped in preventing and curing these disorders by suppression of ROS and by inhibition of multiple targets. In this review, we tried to explain various neuropathological conditions with their target sites and neurobiological mechanisms of morin.
神经退行性疾病可能成为未来几年全球第二大致死原因。神经退行性疾病给医疗保健系统带来了巨大的经济负担，同时也给家庭和患者带来了深远的影响。目前仍缺乏针对这些疾病的、经证实有效的、可改变疾病进程的治疗策略。有文献证明氧化应激在许多神经退行性疾病的病理生理学中起着主导作用。具有良好抗氧化特性的分子可以被探索用于治疗这些疾病。生物类黄酮桑色素的神经保护作用在文献中得到了很好的证实。桑色素作为一种超强抗氧化剂，通过抑制 ROS 和抑制多个靶点，有助于预防和治疗这些疾病。在这篇综述中，我们试图用桑色素的靶位和神经生物学机制来解释各种神经病理学状况。
