建模单核铜单加氧酶中的“组氨酸臂”基序。
Modelling a 'histidine brace' motif in mononuclear copper monooxygenases.
机构信息
Department of Material and Life Science, Division of Advanced Science and Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
出版信息
Chem Commun (Camb). 2020 May 11;56(38):5123-5126. doi: 10.1039/d0cc01392g. Epub 2020 Apr 16.
PMID:32297615
Abstract
A mononuclear copper complex bearing a 'histidine brace' is synthesised and characterised as an active-site model of mononuclear copper monooxygenases such as lytic polysaccharide monooxygenases (LPMOs) and particulate methane monooxygenase (pMMO). The complex has similar structural and functional features to the active sites of the enzymes.
摘要
合成并表征了一种单核铜配合物，该配合物带有“组氨酸支链”，作为溶菌多糖单加氧酶（LPMOs）和颗粒甲烷单加氧酶（pMMO）等单核铜单加氧酶的活性位点模型。该配合物具有与酶的活性位点相似的结构和功能特征。
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