School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China.
Chem Commun (Camb). 2020 May 27;56(42):5621-5624. doi: 10.1039/c9cc10042c.
A practical method for the synthesis of 2H-imidazoles via a [2+3] annulation of N-H imines with vinyl azides using a copper catalyst is developed. In this conversion, environmentally friendly oxygen is used as the sole oxidant and N2 and H2O are the only by-products. The catalytic transformation, operating under mild conditions, is operationally simple and is considered as a readily available catalytic system having good substrate and functional compatibility with high atom-efficiency without the need for additional ligands or additives.
一种实用的方法通过铜催化剂的 N-H 亚胺与乙烯基叠氮化物的[2+3]环加成合成 2H-咪唑。在这种转化中，环境友好的氧气被用作唯一的氧化剂，N2 和 H2O 是唯一的副产物。该催化转化在温和条件下进行，操作简单，被认为是一种易得的催化体系，具有良好的底物和功能兼容性，原子经济性高，无需额外的配体或添加剂。
