Liu Min, Liu Bifu, Chen Hongyan, Wang Qian, Liu Lixin, Feng Kejun, Wang Zijia, Li Qiang
School of Chemistry and Materials Engineering, Huizhou University, Huizhou 516007, China.
Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry and Chemical Engineering, Liaocheng University, No. 1, Hunan Street, Liaocheng, Shandong 252000, P. R. China.
Org Biomol Chem. 2024 Sep 18;22(36):7316-7320. doi: 10.1039/d4ob00977k.
A facile and practical protocol to construct 2-imidazoles by applying an oxime acetate block as the sole component oxidative homo/cross-coupling catalyzed by Cu(I) was developed. This strategy provides a straightforward method to produce a series of substituted 2-imidazoles in moderate to excellent yields. The transformation process is straightforward to operate and is considered as a readily available catalytic system exhibiting good substrate compatibility, eliminating the necessity for pre-functionalization of azides or the use of additives.
开发了一种简便实用的方法，通过使用乙酸肟酯作为唯一组分，在Cu(I)催化下进行氧化均相/交叉偶联反应来构建2-咪唑。该策略提供了一种直接的方法，以中等至优异的产率制备一系列取代的2-咪唑。该转化过程操作简便，被认为是一种易于获得的催化体系，具有良好的底物兼容性，无需叠氮化物的预官能化或使用添加剂。
