Department of Chemistry and Pharmacy, Institute for Biochemistry, University of Münster, Wilhelm-Klemm-Straße 2, 48149 Münster, Germany.
Cells in Motion Interfaculty Center, Waldeyerstraße 15, 48149 Münster, Germany.
Biochemistry. 2020 May 5;59(17):1650-1655. doi: 10.1021/acs.biochem.0c00181. Epub 2020 Apr 24.
Melanoma is a life-threatening disease caused by mutations in pigment-producing cells. Numerous treatments for melanoma have been approved in the past several decades; however, they often cause severe side effects and in most cases do not result in a complete cure. mRNA (messenger RNA) as a therapeutic agent provides a new avenue for melanoma treatment and several advantages over conventional treatments. The first mRNA drugs for melanoma treatment are currently in clinical trials, and approval of mRNA drugs by the Food and Drug Administration seems to be within reach. This new class of drugs can be readily adapted to other diseases, raising the hope of providing a new therapeutic option for various diseases.
黑色素瘤是一种由色素生成细胞突变引起的危及生命的疾病。在过去的几十年中，已经批准了许多用于治疗黑色素瘤的方法；然而，它们经常会引起严重的副作用，而且在大多数情况下，无法完全治愈。信使 RNA（mRNA）作为一种治疗剂，为黑色素瘤的治疗提供了新的途径，并且与传统治疗方法相比具有许多优势。目前，用于黑色素瘤治疗的第一批 mRNA 药物正在临床试验中，美国食品和药物管理局似乎即将批准 mRNA 药物。这种新型药物可以很容易地适应其他疾病，为各种疾病提供新的治疗选择。
