R. Paul McClung and Caroline Castillo are with the Epidemic Intelligence Service, Division of Scientific Education and Professional Development, Centers for Disease Control and Prevention (CDC), Atlanta, GA. Mateusz Karwowski, Sarah Collier, Eija Trees, Elizabeth Adam, Hannah Reses, Jennifer Cope, Katie Fullerton, Vincent Hill, and Jonathan Yoder are with the Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, CDC, Atlanta. Jevon McFadden, Jim Collins, and Ashley Miller are with the Michigan Department of Health and Human Services, Lansing. Marty Soehnlen and Stephen Dietrich are with the Bureau of Laboratories, Michigan Department of Health and Human Services, Lansing. Grete Wilt is with the Division of Toxicology and Human Health Sciences, Geospatial Research, Analysis, and Services Program (GRASP), CDC, Atlanta. Christina Harrington is with the Saginaw County Health Department, Saginaw, MI.
Am J Public Health. 2020 Jun;110(6):842-849. doi: 10.2105/AJPH.2020.305577. Epub 2020 Apr 16.
To investigate a shigellosis outbreak in Genesee County, Michigan (including the City of Flint), and Saginaw County, Michigan, in 2016 and address community concerns about the role of the Flint water system. We met frequently with community members to understand concerns and develop the investigation. We surveyed households affected by the outbreak, analyzed isolate data, examined the geospatial distribution of cases, and reviewed available water quality data. We surveyed 83 households containing 158 cases; median age was 10 years. Index case-patients from 55 of 83 households (66%) reported contact with a person outside their household who wore diapers or who had diarrhea in the week before becoming ill; results were similar regardless of household drinking water source. Genomic diversity was not consistent with a point source. In Flint, no space-time clustering was identified, and average free chlorine residual values remained above recommended levels throughout the outbreak period. The outbreak was most likely caused by person-to-person contact and not by the Flint water system. Consistent community engagement was essential to the design and implementation of the investigation.
为调查 2016 年密歇根州杰纳西县(包括弗林特市)和萨吉诺县的志贺氏菌病暴发情况,并回应社区对弗林特供水系统所扮演角色的关切,我们与社区成员频繁会面,以了解关切并开展调查。我们对受疫情影响的家庭进行了调查,分析了分离株数据,检查了病例的地理空间分布,并审查了现有水质数据。我们调查了 83 户家庭,共 158 例;中位年龄为 10 岁。83 户家庭中的 55 户(66%)的索引病例报告在发病前一周与家中以外穿着尿布或腹泻的人有过接触;无论家庭饮用水源如何,结果都相似。基因组多样性与单一污染源不一致。在弗林特,未发现时空聚集,整个疫情期间,平均游离氯余氯值仍保持在推荐水平之上。此次疫情很可能是由人与人之间的接触引起的,而非弗林特供水系统。持续的社区参与对于调查的设计和实施至关重要。