追踪新兴肠道病原体地方性流行种群的建立。
Tracking the establishment of local endemic populations of an emergent enteric pathogen.
机构信息
Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC 3010, Australia.
出版信息
Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17522-7. doi: 10.1073/pnas.1308632110. Epub 2013 Sep 30.
Abstract
Shigella sonnei is a human-adapted pathogen that is emerging globally as the dominant agent of bacterial dysentery. To investigate local establishment, we sequenced the genomes of 263 Vietnamese S. sonnei isolated over 15 y. Our data show that S. sonnei was introduced into Vietnam in the 1980s and has undergone localized clonal expansion, punctuated by genomic fixation events through periodic selective sweeps. We uncover geographical spread, spatially restricted frontier populations, and convergent evolution through local gene pool sampling. This work provides a unique, high-resolution insight into the microevolution of a pioneering human pathogen during its establishment in a new host population.
摘要
宋内志贺菌是一种适应人类的病原体，它正在全球范围内成为细菌性痢疾的主要病原体。为了研究其在当地的定植情况，我们对 263 株分离自越南的宋内志贺菌进行了全基因组测序，这些菌株的采集时间跨越 15 年。我们的数据表明，宋内志贺菌于 20 世纪 80 年代传入越南，并在当地经历了克隆扩张，同时还伴随着周期性的选择清除事件，导致了基因组的固定。我们发现了该菌通过局部基因库采样实现的地理传播、空间受限的前沿种群和趋同进化。本研究为一种先驱性人类病原体在新宿主种群中建立过程的微观进化提供了独特的、高分辨率的见解。
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