依赖接触的细菌间拮抗作用由蛋白质分泌机器介导。
Contact-Dependent Interbacterial Antagonism Mediated by Protein Secretion Machines.
机构信息
Michael DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON, Canada L8S 4K1; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada L8S 4K1.
Michael DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON, Canada L8S 4K1; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada L8S 4K1; David Braley Centre for Antibiotic Discovery, McMaster University, Hamilton, ON, Canada L8S 4K1.
出版信息
Trends Microbiol. 2020 May;28(5):387-400. doi: 10.1016/j.tim.2020.01.003. Epub 2020 Feb 12.
To establish and maintain an ecological niche, bacteria employ a wide range of pathways to inhibit the growth of their microbial competitors. Some of these pathways, such as those that produce antibiotics or bacteriocins, exert toxicity on nearby cells in a cell contact-independent manner. More recently, however, several mechanisms of interbacterial antagonism requiring cell-to-cell contact have been identified. This form of microbial competition is mediated by antibacterial protein toxins whose delivery to target bacteria uses protein secretion apparatuses embedded within the cell envelope of toxin-producing bacteria. In this review, we discuss recent work implicating the bacterial Type I, IV, VI, and VII secretion systems in the export of antibacterial 'effector' proteins that mediate contact-dependent interbacterial antagonism.
为了建立和维持生态位，细菌采用了多种途径来抑制其微生物竞争者的生长。其中一些途径，如产生抗生素或细菌素的途径，以非细胞接触依赖的方式对附近的细胞产生毒性。然而，最近已经确定了几种需要细胞间接触的细菌间拮抗作用机制。这种形式的微生物竞争是由抗菌蛋白毒素介导的，其将毒素输送到靶细菌使用的是嵌入在产毒细菌细胞包膜中的蛋白分泌装置。在这篇综述中，我们讨论了最近的工作，这些工作表明细菌 I 型、IV 型、VI 型和 VII 型分泌系统在导出介导接触依赖性细菌间拮抗作用的抗菌“效应”蛋白方面的作用。
Zotero 插件