Ferrer-Pérez Carmen, Reguilón Marina D, Miñarro José, Rodríguez-Arias Marta
Department of Psychobiology, Faculty of Psychology, Universitat de València, Valencia, Spain.
Department of Psychobiology, Faculty of Psychology, Universitat de València, Valencia, Spain.
Physiol Behav. 2020 Jul 1;221:112913. doi: 10.1016/j.physbeh.2020.112913. Epub 2020 Apr 13.
Social factors have a dual influence on addictive disorders. While social defeat stress in rodents increases the response to drug reward, positive social conditions, such as pair housing, increase stress resilience. The objective of the present study was to confirm whether oxytocin (OT) mediates this social buffering. To this end, male mice were housed in pairs and administered the OT receptor antagonist atosiban prior to each stress episode or for ten days after the stress protocol. The response to cocaine was assessed using a conditioned place preference paradigm. Our results confirmed that OT activity mediates the protective effect of pair housing and highlights its therapeutic potential.
社会因素对成瘾性障碍具有双重影响。啮齿动物遭受社会挫败应激会增强对药物奖赏的反应，而诸如成对饲养等积极的社会条件则会增强应激恢复力。本研究的目的是确认催产素（OT）是否介导这种社会缓冲作用。为此，将雄性小鼠成对饲养，并在每次应激发作前或应激方案实施后的十天内给它们注射OT受体拮抗剂阿托西班。使用条件性位置偏爱范式评估对可卡因的反应。我们的结果证实，OT活性介导了成对饲养的保护作用，并突出了其治疗潜力。
