Department of Nephrology, The People's Hospital of Guizhou Province, 550002, Guiyang, Guizhou, China; Department of Infectious Diseases, People's Hospital of Tongren, 554300, Tongren, Guizhou, China.
Department of Nephrology, The People's Hospital of Guizhou Province, 550002, Guiyang, Guizhou, China.
Int J Antimicrob Agents. 2020 Aug;56(2):105974. doi: 10.1016/j.ijantimicag.2020.105974. Epub 2020 Apr 13.
Here we report a case of a laboratory-confirmed 2019 novel coronavirus (2019-nCoV)-infected patient with COVID-19 (coronavirus disease 2019) who developed respiratory failure and shock accompanied by persistent diarrhoea despite conventional therapeutic interventions. The patient avoided mechanical ventilation and showed an immediate clinical and radiological improvement following treatment with intensive plasma exchange (PE) followed by intravenous immunoglobulin (IVIG). Successful therapeutic strategies in this case suggest that timely initiation of PE treatment followed by IVIG in critically ill patients with COVID-19 may prevent the disease from worsening and help to reduce the requirement for mechanical ventilation and intensive supportive care. Moreover, it may improve poor clinical outcomes of these patients.
在这里，我们报告了一例实验室确诊的 2019 年新型冠状病毒（2019-nCoV）感染患者，该患者患有 COVID-19（2019 年冠状病毒病），尽管进行了常规治疗干预，但仍出现呼吸衰竭和休克，并伴有持续性腹泻。该患者避免了机械通气，并在接受强化血浆置换（PE）联合静脉注射免疫球蛋白（IVIG）治疗后，临床和影像学均迅速改善。该病例的成功治疗策略表明，对于 COVID-19 重症患者，及时启动 PE 治疗，随后使用 IVIG，可能阻止病情恶化，并有助于减少对机械通气和强化支持治疗的需求。此外，它可能改善这些患者的不良临床结局。
