Natural Products Laboratory, Research and Development Department, Reyoung Pharmaceutical Co.,Ltd. Jinan Branch, Jinan, 250012, China.
Department of Natural Products Chemistry, Key Laboratory of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Fitoterapia. 2020 Jul;144:104594. doi: 10.1016/j.fitote.2020.104594. Epub 2020 Apr 14.
Phytochemical investigation of the roots of Pueraria lobata led to the isolation of two pairs of new isoflavone glucosides, 3'-hydroxyneopuerarin A/B (1-2) and 3'-methoxyneopuerarin A/B (3-4). A pair of known compounds (5-6), which possess a very similar structure, were obtained together. Their structures were elucidated on the basis of spectroscopic data interpretation. Compounds 3-6 dose-dependently blocked the production of TNF-α and IL-6 in LPS-stimulated RAW264.7 cells, which indicated the potential anti-inflammatory effect of these compounds.
对葛根的根进行的植物化学研究导致分离出两对新的异黄酮葡萄糖苷，3'-羟基新葛根素 A/B（1-2）和 3'-甲氧基新葛根素 A/B（3-4）。还一起获得了一对具有非常相似结构的已知化合物（5-6）。基于光谱数据解释，阐明了它们的结构。化合物 3-6 可剂量依赖性地阻断 LPS 刺激的 RAW264.7 细胞中 TNF-α和 IL-6 的产生，表明这些化合物具有潜在的抗炎作用。
