溶瘤 ECHO-7 病毒株 Rigvir 对葡萄膜黑色素瘤细胞系的影响。
Effect of oncolytic ECHO-7 virus strain Rigvir on uveal melanoma cell lines.
机构信息
Rigvir, Atlasa iela 7C, LV-1026, Riga, Latvia.
University of Latvia, Jelgavas iela 1, LV-1004, Riga, Latvia.
出版信息
BMC Res Notes. 2020 Apr 16;13(1):222. doi: 10.1186/s13104-020-05068-4.
OBJECTIVE
Uveal melanoma is a rare intraocular malignancy. Half of the patients diagnosed will develop metastases within 10 to 30 years, most commonly in the liver. Although there has been a significant development in the treatment of melanoma, no effective treatment to prevent or treat metastases of uveal melanoma is available. Oncolytic viruses are now being studied for various types of cancers and show promising results. Preclinical results show cytolytic activity of enteric cytopathic human orphan virus type 7 (ECHO-7) strain Rigvir in human melanoma, rhabdomyosarcoma, gastric adenocarcinoma, lung carcinoma and pancreas adenocarcinoma cell lines. The aim of this study was to test the possible cytolytic activity in human uveal melanoma cell lines.
RESULTS
The results suggest cytolytic activity of oncolytic ECHO-7 virus strain Rigvir in MP41, 92-1 and Mel-202 cell lines.
目的
葡萄膜黑色素瘤是一种罕见的眼内恶性肿瘤。诊断出的患者中有一半将在 10 到 30 年内发展为转移，最常见的转移部位是肝脏。尽管黑色素瘤的治疗已有显著进展，但目前尚无有效的预防或治疗葡萄膜黑色素瘤转移的方法。溶瘤病毒目前正在研究用于治疗各种类型的癌症，并显示出有希望的结果。临床前研究结果表明，肠道细胞病变孤儿病毒 7 型（ECHO-7）株 Rigvir 在人黑色素瘤、横纹肌肉瘤、胃腺癌、肺癌和胰腺腺癌细胞系中具有细胞溶解活性。本研究旨在检测溶瘤 ECHO-7 病毒株 Rigvir 在人葡萄膜黑色素瘤细胞系中的潜在细胞溶解活性。
结果
结果表明，溶瘤 ECHO-7 病毒株 Rigvir 在 MP41、92-1 和 Mel-202 细胞系中具有细胞溶解活性。
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