γδ TCR 对 MR1 的识别：适应翻转的生活。
γδ TCR Recognition of MR1: Adapting to Life on the Flip Side.
机构信息
Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK; Cancer Immunology and Immunotherapy Centre, University of Birmingham, Birmingham, UK.
Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK; Cancer Immunology and Immunotherapy Centre, University of Birmingham, Birmingham, UK.
出版信息
Trends Biochem Sci. 2020 Jul;45(7):551-553. doi: 10.1016/j.tibs.2020.03.012. Epub 2020 Apr 13.
Nonclassical class I MHC-like molecules are ligands for several unconventional T cell populations. Recently, Le Nours et al. identified human γδ T cells recognising MHC-related protein-1 (MR1) via their T cell receptor (TCR). Also recognised by the αβ-TCR of mucosal associated invariant T cells, MR1 interacts with specific γδ-TCRs using strikingly diverse binding modes, suggesting fundamental differences in γδ T cell recognition.
非经典 I 类 MHC 样分子是几种非常规 T 细胞群体的配体。最近，Le Nours 等人鉴定了人 γδ T 细胞通过其 T 细胞受体（TCR）识别 MHC 相关蛋白-1（MR1）。黏膜相关不变 T 细胞的 αβ-TCR 也能识别 MR1，MR1 与特异性 γδ-TCR 以明显不同的结合模式相互作用，表明 γδ T 细胞识别存在根本差异。
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