Minkov N, Zlatanov Z, Zozikov B, Atanasova M
Vutr Boles. 1985;24(1):54-62.
The authors present their results from the treatment of urological infections with the new semisynthetic penicillin antibiotic azlocillin (acyl-ureide-penicillin) in 86 patients with various, in kind and clinical manifestations, infections of the urinary system. The susceptibility was determined of the isolated bacterial causative agents of the urological infections to azlocillin and to the other antibacterial preparations available in our country. It was established that 52,7% of Gram-negative microorganisms were susceptible to the preparation, and over 80%--of the Gram-positive microorganisms. The highest number of susceptible strains were established in pseudomonas, coli, enterobacter, klebsiella and proteus. The results from the clinical study reveal that 51,2% of the patients were cured by the end of the therapeutic course and abatement or considerable improvement, was observed in all, of the clinical and paraclinical indices, suggesting urological infection. No allergic or toxic manifestations were observed. The absence of nephrotoxicity makes that new, for our practice, antibiotic extremely valuable for the patients with renal insufficiency. The most general conclusion from that study is that azlocillin, with its effectiveness, comes close to the most potent modern antibacterial preparations, with no toxicity characteristic for aminoglucoside antibiotics.
作者介绍了用新型半合成青霉素抗生素阿洛西林（酰脲类青霉素）治疗86例患有各种类型和临床表现的泌尿系统感染患者的结果。测定了泌尿系统感染分离出的细菌病原体对阿洛西林以及我国现有的其他抗菌制剂的敏感性。结果表明，52.7%的革兰氏阴性微生物对该制剂敏感，80%以上的革兰氏阳性微生物敏感。在假单胞菌、大肠杆菌、肠杆菌、克雷伯菌和变形杆菌中发现的敏感菌株数量最多。临床研究结果显示，51.2%的患者在治疗疗程结束时治愈，所有提示泌尿系统感染的临床和辅助检查指标均有减轻或显著改善。未观察到过敏或毒性表现。无肾毒性这一点使得这种对我们的实践来说新型的抗生素对肾功能不全患者极为有价值。该研究最普遍的结论是，阿洛西林有效性接近最有效的现代抗菌制剂，且没有氨基糖苷类抗生素的毒性特征。
