Health Science Center, Xi'an Jiaotong University, No. 76 Yanta West Road, Xi'an, 710061, Shaan Xi, China.
Blood Purification Department, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaan Xi, China.
Int Urol Nephrol. 2020 May;52(5):969-976. doi: 10.1007/s11255-020-02459-1. Epub 2020 Apr 16.
Insufficient dialysis is a difficult problem for patients undergoing hemodialysis, and causes cardiovascular complications and increases mortality. Increasing aerobic exercise and resistance exercise have been shown to be beneficial to physical fitness of patients undergoing hemodialysis, but a few studies have focused on combined exercise (combination of aerobic and resistance exercise training) and the interaction effect of combined exercise and intervention duration on hemodialysis efficiency. This study aimed to investigate the effects of 24-week combined exercise on hemodialysis efficiency, blood pressure, exercise capacity, and quality of life in patients undergoing hemodialysis.
In total, 47 eligible subjects were randomly allocated to exercise group and control group. The intervention group performed a 24-week, three times weekly, and moderate-intensity intradialytic combined exercise. Patients in the control group received usual care. The primary outcome was hemodialysis efficiency, which recorded every 4 weeks. Secondary outcomes included blood pressure, exercise capacity, and quality of life, measured at baseline and after 24 weeks of intervention.
In intervention group, sp Kt/V significantly improved by 13.2%, and systolic blood pressure and diastolic blood pressure significantly decreased by 8.5 mmHg and 6.5 mmHg, respectively. The 6-min walking distance increased significantly by 43 m (9.8%), but there was no significant change in quality of life.
Combined exercise and intervention duration had an interaction effect on hemodialysis efficiency. Combined exercise improved blood pressure and physical fitness for patients undergoing hemodialysis, but did not affect quality of life. The extensive benefits of combined exercise provide evidence for the exercise development for patients undergoing hemodialysis.
透析不充分是血液透析患者面临的一个难题，可导致心血管并发症并增加死亡率。已证实，增加有氧运动和抗阻运动有益于血液透析患者的身体健康，但很少有研究关注联合运动（有氧运动和抗阻运动训练的结合）以及联合运动和干预持续时间对血液透析效率的交互作用。本研究旨在探讨 24 周联合运动对血液透析效率、血压、运动能力和血液透析患者生活质量的影响。
共有 47 名符合条件的受试者被随机分配到运动组和对照组。干预组进行了 24 周、每周 3 次、中等强度的透析内联合运动。对照组接受常规护理。主要结局是血液透析效率，每 4 周记录一次。次要结局包括血压、运动能力和生活质量，在基线和 24 周干预后测量。
在干预组中，spKt/V 显著提高了 13.2%，收缩压和舒张压分别显著降低了 8.5mmHg 和 6.5mmHg。6 分钟步行距离显著增加了 43m（9.8%），但生活质量没有显著变化。
联合运动和干预持续时间对血液透析效率有交互作用。联合运动改善了血液透析患者的血压和身体状况，但对生活质量没有影响。联合运动的广泛益处为血液透析患者的运动发展提供了证据。
