Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Department of Woman and Child Health Care, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Pediatr Allergy Immunol. 2020 Aug;31(6):662-670. doi: 10.1111/pai.13254. Epub 2020 Apr 29.
Eczema is a growing threat on infants' health, and the role of maternal depression in the risk of eczema's early onset is unclear. This study aimed to examine the associations of different exposure timing of prenatal depressive symptoms with offspring's eczema in infancy.
The study was part of the ongoing prospective Born in Guangzhou Cohort Study. Maternal depressive symptoms were assessed at both early (<20th week of gestation) and late pregnancy (≥33rd week of gestation to delivery) using the Self-Rating Depression Scale. Information on the diagnosis of eczema was collected when the children were 1 year old. Multivariable logistic regression was used to examine the association between prenatal depressive symptoms and infants' eczema and test for moderation by parental history of allergic diseases.
In this population, 7.7% (447/5825) of mothers experienced persistent depressive symptoms during pregnancy, 10.1% (590/5825) had depressive symptoms only at early pregnancy, and 8.4% (489/5825) of women experienced depressive symptoms only at late pregnancy. After adjusting for potential confounders, higher risks of eczema were observed in infants of mothers with persistent prenatal depressive symptoms when compared to those children without maternal depressive symptoms throughout pregnancy (OR: 1.55, 95% CI 1.19-2.03). These associations were marginally more pronounced among children in families without parents affected by allergic diseases than in other families (P for interaction = .064 for courses of prenatal depressive symptoms).
Persistent maternal depressive symptoms during pregnancy increased the risk of infants' eczema, especially in children without family history of allergic diseases. These associations, if proved to be causal, could be an intervention target not only to improve women's health but also to prevent offspring's eczema.
湿疹是婴儿健康面临的日益严重的威胁，而产妇抑郁在湿疹早期发病风险中的作用尚不清楚。本研究旨在探讨产前抑郁症状不同出现时间与婴儿期湿疹的关系。
本研究是正在进行的广州出生队列研究的一部分。采用自评抑郁量表在妊娠早期（<20 孕周）和妊娠晚期（≥33 孕周至分娩）评估产妇抑郁症状。当孩子 1 岁时，收集关于湿疹诊断的信息。多变量逻辑回归用于检验产前抑郁症状与婴儿湿疹之间的关系，并检验父母过敏病史的调节作用。
在该人群中，7.7%（447/5825）的母亲在怀孕期间持续出现抑郁症状，10.1%（590/5825）的母亲仅在妊娠早期出现抑郁症状，8.4%（489/5825）的母亲仅在妊娠晚期出现抑郁症状。调整潜在混杂因素后，与整个孕期无产妇抑郁症状的婴儿相比，患有持续性产前抑郁症状的母亲所生婴儿患湿疹的风险更高（OR：1.55，95%CI 1.19-2.03）。这些关联在父母双方均未患过敏疾病的家庭中的儿童中比在其他家庭中更为明显（产前抑郁症状进程的交互作用 P 值为.064）。
妊娠期间持续的产妇抑郁症状增加了婴儿患湿疹的风险，尤其是在没有家族过敏史的儿童中。如果这些关联被证明是因果关系，它们可能不仅是改善妇女健康的干预目标，也是预防子女患湿疹的目标。
